- Open Access
Otitis media with effusion and atopy: is there a causal relationship?
- Mario E. Zernotti†1Email author,
- Ruby Pawankar†2,
- Ignacio Ansotegui3,
- Hector Badellino4,
- Juan Sebastian Croce5,
- Elham Hossny6,
- Motohiro Ebisawa7,
- Nelson Rosario8,
- Mario Sanchez Borges9,
- Yuan Zhang10 and
- Luo Zhang10
© The Author(s). 2017
- Received: 22 January 2017
- Accepted: 13 September 2017
- Published: 14 November 2017
Otitis Media with Effusion (OME) is an inflammatory condition of the middle ear cleft, acute or chronic, with collection of fluid in the middle ear with an intact tympanic membrane. It is a very common disease in childhood, the most frequent cause of hearing loss in childhood and often requiring surgery. OME is called chronic when the fluid in the middle ear persists for more than three months or when the episodes recur six or more times in one year. The current article covers various aspects of OME including definition, epidemiology. Pathomechanisms, risk factors, role of allergy in OME, impact of upper airway disease on OME, eosinophilic otitis media and management of OME.
- Risk factors
- Inflammation; eosinophilic otititis media
OME is the most common disease of the ear in childhood and the most common cause of hearing loss in childhood. Eighty percent of all children have had an episode of this disease by the age of 10 years, mostly by the age of 3 years. The prevalence is about 20% at the age of 2 years with a decreases in prevelance to 8% at the age of 8 years. More than half of these cases are preceded by an acute otititis media (AOM). Dysfunction of the Eustachian tube plays a key role in the development of OME. OME is considered to be a multifactorial disease, which clinically appears on different levels, caused by predisposing factors. Sequence of birth and gender are predisposing factors. Younger siblings as well as children visiting nursery school and smoking by the mother are among the various risk factors. The role of allergic disease in the pathogenesis of OME has been investigated intensively in the last years. There is a broad association from 5 to 80% in childhood.
Otitis Media with Effusion (OME), also known as “Glue Ear” or “Secretory Otitis Media”, is an inflammatory condition of the middle ear cleft, acute or chronic, with collection of non-purulent fluid behind an intact tympanic membrane. It is the most frequent cause of hearing loss in childhood and the most common reason for surgery [1, 2]. OME is called chronic when the fluid persists for more than three months or when the episodes recur six or more times in twelve months [1, 3].
Epidemiological data about OME are controversial and disparate. This disease, which especially affects children, shows a prevalence of 0.6% among adults, in contrast to the fact that 90% of children under two years have had at least one episode and about 80% of preschool children experience OME.
Prevalence of OME has a seasonal maximum in winter and a minimum in summer .
Predisposing factors of Otitis Media with Effusion (OME)
- Male Sex
- Craniofacial abnormalities (e.g. cleft palate)
- Day-care school and attendance
- Adenoid hypertrophy
- Tobacco smoke exposure
- Upper airway infection (acute otitis, chronic rhinosinusitis, infective rhinitis)
- Extreme pre-term
The role of allergic disease in the pathogenesis of OME has been investigated intensively in recent years. An allergy-triggered cascade is supposed to cause obstruction of the Eustachian tube, which again could lead to an OME [6–9]. In a cohort study, OME was associated with concomitant allergic rhinitis (OR = 2.29, CI = 0.97–5.39, P = 0.058) but not with non-allergic rhinitis, asymptomatic sensitization, asthma or eczema . But this association seems to be significant in children 6 years of age and older; whereas there is no significant association in younger children .
Patients with otitis media with effusion present different grades of conductive hearing loss according to the type of fluid or effusion (serous or mucous) . Autophony and tinnitus are usual as symptoms. Hearing loss can range from 15 to 40 dB . These symptoms, (without pain) do not cause children to complain because they are a silent process. Some levels of distraction or poor school performance are indirect signs to consider . Symptoms are often mild or minimal. They can vary based on a child’s age.
Initially the effusion is serous as a transudate. Then, due to the histological changes of the middle ear mucosa (by an increase of goblet cell metaplasia and mucus glands), the liquid becomes seromucous, then mucoid and finally, the effusion becomes thick and stringy, like a glue (gummy ear). On the tympanic membrane which is originally intact, some trophic changes appear and the presence of atelectasis due to negative pressure and subsequent retraction (pockets) is common in chronic processes . These are the sources of more complicated diseases such as chronic otitis media or cholesteatoma.
Apart from the classic clinical features mentioned above, in 1984 Tomioka  described a new clinical pattern characterized by high resistance to treatment associated with asthma and nasal polyposis. These patients have a marked viscosity, and this effusion is characterized by high numbers of eosinophils. This special presentation of otitis media with effusion is called eosinophilic otitis media. Another feature is that these patients have a higher prevalence of atopy.
Symptoms and correlation with signs
Conductive hearing loss
Autophony or fullness
Visible fluid behind the eardrum
Dullness (Lost of Politzer bright triangle)
Eosinophilic otitis media (EOM) is an intractable form of otitis media characterized by the presence of a highly viscous yellow effusion containing eosinophils. EOM shows a very high rate of association with asthma. It is resistant to conventional treatments for otitis media. However, EOM associated with adult-onset asthma has been shown to improve following optimal asthma therapy [16, 17]. EOM predominantly affects women in their fifties.
High-tone hearing loss is more frequently found and more severe in EOM patients, and sudden deafness is also seen sometimes. EOM occurs bilaterally, mostly, although the onset of disease in each ear may differ. EOM is often associated with asthma both in non-atopic and atopic asthmatics. Studies looking at the relation of EOM and asthma severity have shown that asthma severity was statistically greater in patients with EOM than in patients without EOM. EOM is often complicated by eosinophilic rhinosinusitis [18, 19]. Moreover, there was a close relationship between EOM and asthma severity in asthma patients with chronic rhinosinusitis.
A significantly larger number of EG2- positive cells was observed in the middle ear mucosa of EOM patients than that of the control group (COM without bronchial asthma), proving that active eosinophilic inflammation is occurring in these patients . Eosinophil chemoattractants like interleukin (IL)-5 and eotaxin, regulated on activation, normal T-cell expressed and secreted (RANTES); and ecalectin in middle ear effusion (MEE) are significantly higher in EOM patients than in controls [20, 21], not only at the protein level but also at the mRNA level, indicating that active eosinophilic inflammation occurs in the middle ear itself. The levels of ECP were found to correlate positively with that of IL-5, suggesting that IL-5 may play a crucial role in the accumulation of eosinophils in the middle ear . Immunohistochemically, IL-5+ and ecalectin + cells are significantly increased in the middle ear mucosa of EOM patients as compared with that of the control group. Levels of IL-5 in MEE were significantly higher than those in blood in both groups of patients and in OME patients with asthma than in the control group. In addition, in OME patients with asthma, there was a significant correlation between the percentage of eosinophils and IL-5 levels in MEE . Eotaxin levels in blood were significantly higher than those in MEE and eosinophilia in MEE depends more on IL-5 than on eotaxin, thus mobilizing eosinophils from the bone marrow into the blood.
In patients with EOM, 62% of patients (62%) versus 11% of control patients (11%) had antigen-specific IgE in the middle ear effusion although no difference was noted in the total serum IgE concentrations . The severity score of EOM in the antigen-specific IgE-positive group was significantly higher than that in the antigen-specific IgE-negative group suggesting that antigen-specific IgE against inhalant and bacterial antigens may be locally produced in the middle ear mucosa in patients with EOM. In particular, local sensitization against fungi together with Staphylococcus aureus could result in local IgE production in the middle ear and may be responsible for the severity of EOM. The IgE positive cells were mainly mast cells, but also partially in the cytoplasm of cells that appeared to be plasma cells indicating the production of IgE locally in the middle ear mucosa. The existence of high-level IgE may exacerbate eosinophilic inflammation in the middle ear. The concentration of IgE in middle ear effusion significantly and positively correlated with bone conduction hearing levels at 2 kHz and 4 kHz in EOM patients. Overproduction of IgE locally in the middle ear may be related to the pathological condition of EOM and eventually cause inner ear damage.
Sixty-one percent of patients had extensive activation of mast cells in their middle ears . Among those with elevated tryptase in their effusion, 95.6% were atopic and 94.7% also had elevated effusion eosinophilic cationic protein. Tryptase was elevated only in the effusion of atopic patients as compared with controls. Thus, in asthmatic patients who have a T-helper type 2–dominant predisposition, a patulous eustachian tube easily allows the entry of antigenic materials into the middle ear, causing an eosinophil-dominant inflammation. Eosinophils increase the production of mucin; and cytotoxic proteins derived from eosinophils impair the epithelial cells leading to a debris of infiltrating cells and epithelial cells mixed with excessively produced mucin, generating a more viscous effusion.
The etiology of OME is believed to be multifactorial; with many different factors implicated in the pathophysiology of the disease [25–30]. Although dysfunction of the Eustachian tube (ET) is considered to be the main factor responsible for the development of OME , other host factors associated with the onset of OME include: upper respiratory tract infections (URTIs); mechanical obstruction of the nasopharynx by adenoid hypertrophy or craniofacial malformations such as cleft lip and palate  and Down’s syndrome [32, 33]; allergic and immunologic factors [34–36]; bacterial biofilms [37, 38]; and genetic factors [39, 40]. OME may occur as a consequence of acute otitis media (AOM) taking an extended period of time to resolve . It is also now recognized that bacterial biofilms are crucial in the aetiopathogenesis of OME [37, 38, 42]. Confocal laser scanning microscopy has shown that bacterial biofilms are present as three-dimensional bacterial clusters encased in a self-produced amorphous extracellular matrix attached to a surface within the middle ear , and thought to exert a chronic inflammatory stimulus leading to OME. Similarly, recent guidelines from otologists, pediatricians, and allergists also support the role of allergy in the development of OME, based on clinical evidence [43–46]. Furthermore, there is some evidence that environmental and socioeconomic factors may also influence the pathogenesis of OME, such as: seasonal factors, history of allergy, the level of humidity, accessibility to health services, socioeconomic status, breast feeding duration, communal living environment, unhygienic habits, passive smoking and gastroesophageal reflux [47–52].
When untreated, OME may lead to the development of adhesive otitis media, tympanic membrane abnormalities (e.g. chronic ear drainage), tympanic sclerosis, cholesterol granuloma, acquired primary cholesteatoma, other infections such as meningitis, and other sequelae [54–57]. Moreover, OME is associated with hearing loss and may cause permanent middle ear damage with mucosal changes. The hearing loss in OME is often transient as the middle ear effusion frequently resolves spontaneously, especially if OME follows an episode of AOM . When OME is persistent, particularly if bilateral and early in life, it may impact negatively on speech development, education, and behavior of the affected individual; although the extent to which these features are affected can be variable and controversial . Furthermore, persistent otorrhea and progressive hearing loss often result in a worsening quality of life of the affected individual.
The higher prevalence of otitis media with effusion (OME) in atopic children supported by the predominance of bilateralism and objective hearing loss suggests the important role of allergy in its genesis and recurrence. The prevalence of atopic conditions, including allergic rhinitis (AR) in patients with ROM, ranges from 24% to 89%. OME is often a co-morbidity of AR, while there are few reports on the role of non-allergic rhinitis in its causation [59, 60].
The allergy associated cytokines were assumed to act among the key regulators of the middle ear inflammation of chronic OME . Eustachian tube functions can be affected directly by the mediators released in the nasal mucosa of patients with AR or indirectly by the resultant nasal obstruction . In a multivariable analysis, AR, adenoiditis, and younger age were all shown to be independently associated with a diagnosis of OME . A birth cohort of 291 children from Copenhagen in the 6th year of life revealed an association with AR (OR = 3.36, CI = 1.26–8.96, P = 0.02), but not with nasal mucosal swelling . A significant association was reported between OME, eosinophil cationic protein values in middle ear effusion and persistent symptoms of AR .
The finding of marked elevation of effusion myeloperoxidase in atopic than non-atopic patients suggests that atopy may contribute to elevated levels of neutrophil activity in OME probably due to an enhanced response of the primed inflammatory cells to bacteria . A recent investigation revealed that pro-inflammatory cytokines are found at high concentrations in middle ear effusion of both atopic and non-atopic children which may argue in favor of instituting anti-inflammatory management . Trials of topical intranasal corticosteroids in the management of OME were shown to have promising initial results. However, a double-blind randomized placebo-controlled trial of intranasal corticosteroids in 4–11 year old children with persistent bilateral OME attending a primary health care setting revealed poor response .
OME occurring in the first 2 years of life was found to be associated with AR at 6 years of age as well as other allergic diseases [69, 70]. It was hypothesized that otitis media infections in early life, especially frequent or severe may influence the developing immune system, resulting in greater risk for developing late-onset allergic eczema and asthma during school age especially in those who had three or more attacks of OME [69, 71]. The likelihood of AR and asthma were found higher in patients with serous than with mucous effusion .
Role of IgE mediated allergy in OME
IgE-mediated allergy has long been considered a causative factor in about one third of recurrent OME patients based on clinical observations and skin testing [73–75]. A meta-analysis of 24 studies revealed that the presence of atopy increased the risk of chronic and recurrent otitis media (OR, 1.36; 95% CI, 1.13–1.64; p = 0.001) . Screening of 2320 children revealed a close association between atopy and the development of OME . After multivariate analysis of the data taken from 88 one to seven year old children with OME, IgE sensitization, wheezing, nasal obstruction, family history of otitis, and child-care attendance were the main independent risk factors .
Atopy as indicated by skin prick test (SPT) results was evident in 11 out of 45 (24%) patients undergoing simultaneous tympanostomy tube placement for OME and adenoidectomy for adenoid hypertrophy . In one investigation, 36.4% children with chronic or recurrent otitis media despite adenoidectomy and VT insertion had positive SPT for inhalant and food allergens. Allergy probably plays a more important role in recurrent rather than uncomplicated OME . In another report, the incidence of atopy was 24% among 59 children with persistent OME . SPT results were positive in 51/122 (41.8%) children with chronic OME participating in a randomized controlled trial. Twenty-two percent were positive to house dust mites (HDM), 13.9% to dog/cat allergens, 13.1% to Alternaria/Aspergillus mix, 10.7% to grass, 9.8% to cockroach, and 9% to ragweed .
The association with food allergy was also investigated in several studies. In one study, 78% of 104 unselected patients aged 1.5–9 years with recurrent OME were sensitized to one or more food allergens as revealed by SPT, specific IgE tests, and food challenges. An elimination diet of the suspected food resulted in the amelioration of OME in 86% of patients while reintroduction provoked recurrence in 94% (66/70) of patients over 16 weeks . Recurrent OM has been reported in an extended follow-up of a cohort of 56 children with cow’s milk allergy as compared to 204 control children (27%, versus 12%, p = 0.009) . Both chronic otitis media with effusion and Meniere’s disease were assumed to improve with treatment of food allergies .
Role of IgE mediated allergy in EOM
Antigen-specific IgE against inhalant and bacterial antigens may be locally produced in the middle ear mucosa in patients with eosinophilic otitis media (EOM). One or more antigen-specific IgE antibodies were detected in middle ear effusion of 16 out of 26 patients (62%) with a higher severity score of EOM. Sensitization to fungi and Staphylococcus aureus in particular was observed .
Overproduction of IgE locally in the middle ear may be related to the pathological condition of EOM and eventually cause inner ear damage. The concentration of IgE in middle ear effusion significantly and positively correlated with bone conduction hearing levels at 2 kHz and 4 kHz in EOM patients .
Similarities and differences between upper and lower airway inflammation in allergic rhinitis and rhinosinusitis and middle ear inflammation in OME/EOM
Clinical evidence supports the hypothesis that chronic OME is an allergic disease [44, 90, 91]. Furthermore, allergy is a unique comorbidity of OME and by far a greater risk factor than other identified contributing factors [36, 46, 92, 93]. Middle ear mucosa, which evolves from the same ectoderm as the rest of the upper respiratory tract epithelium, has been found in animal studies to have the same active intrinsic immunologic responsiveness to antigenic stimulus as the nasal tract, sinuses, and bronchi . Indeed, it is now recognized that the upper respiratory tract responds as one unified airway and allergy can affect different target organs at different ages [95–97]. Nguyen and colleagues  have suggested that the middle ear may behave in a “similar manner to the lungs under allergic inflammatory insults” and that the “middle ear may be included in the united airways.” Furthermore, Parietti-Winkler and colleagues [99, 100] have suggested that the development of OME could be considered as a marker of severity of the inflammatory disease leading to nasal polyposis (NP), asthma and aspirin intolerance (AI), and that better characterization of NP patients with OME could allow to define more accurately the nature, type and severity of the underlying inflammatory process.
Although, the most frequently cited objection of past decades linking OME to the allergy hypothesis is that an allergen is unlikely to get into the middle ear itself because of the structural gatekeeper function of the ET , it has been hypothesized that secretory immunity does not rely solely on the premise of direct allergen transport to the middle ear but rather depends on both humoral and cell-mediated immunology . Likewise, histological examination of middle ear effusion has demonstrated the presence of a large number of eosinophils, which are considered to be eosinophilic mucin. However, as not many eosinophils were observed in the middle ear mucosa as in the middle ear effusion, this lead to the speculation that eosinophils that migrated to the middle ear mucosa did not stay locally in the middle ear but migrated immediately to the middle ear cavity. In contrast, as the nasal and paranasal sinus mucosa of patients with AR and eosinophilic chronic rhinosinusitis show extensive accumulation of eosinophils in the submucosa, it is possible that the mechanism/s of eosinophil migration and survival may be different between middle ear mucosa and nasal mucosa of AR and NPs.
Importantly, however, immunoglobulin E (IgE) sensitization, a major contributing factor in multiple airway diseases including AR and NPs, has also been shown to independently increase the risk of OME regardless of mechanical obstruction . This observation further supports the view that the middle ear may serve as a target organ for allergic reactions and that the consequences of atopy are related to defective reactions to external stimuli. Indeed, a recent study by Iino and colleagues  has demonstrated that EOM patients have a significantly higher level of IgE in middle ear effusion compared with control subjects. Furthermore, the IgE level in middle ear effusion was significantly higher than serum IgE level in the EOM patients, suggesting that IgE was likely to be produced locally in the middle ear mucosa . Support for local IgE production comes from increasing recognition of local AR (LAR), a form of AR in a subgroup of idiopathic rhinitis individuals with negative allergy testing in whom inflammation is thought to be mediated by localized IgE, and allergen-specific IgE is also measurable in nasal secretions . Similarly, Bachert and colleagues  have reported significant concentrations of IgE specific to Staphylococcus aureus enterotoxins in NP tissue and suggested that as the patients showed neither increase in serum antigen-specific IgE levels nor positive skin prick test reactions the S. aureus specific IgE was produced locally in the NPs (Fig. 1).
Impact of upper airway or lower airway inflammation on OME/EOM. Is OME/EOM part of the chronic allergic respiratory syndrome?
Recent epidemiological studies support the evidence for the link between otitis media with effusion (OME) and allergy, especially allergic rhinitis (AR) [105, 106]. Roditi et al. used data of 1,491,045,375 pediatric visits from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 2005–2010. They found that age was an effect modifier of the association between AR and OME, and that a significant relationship was observed in children 6 years of age and older, whereas there was no significant association in younger children . Kreiner-Møller et al. also analyzed data obtained from 291 children in the 6th year of life from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) 2000 birth cohort. They reported that OME was diagnosed in 39% of the cohort and was significantly associated with AR, but not with nasal mucosal swelling, nasal eosinophilia, non-allergic rhinitis, asthma or eczema. The frequency of OME in British preschool children was reported from participants in the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC). Midgley et al. reported that there was a decrease in prevalence of OME with increasing age and a marked seasonal effect on the frequency of OME. It seems obvious that a link between AR and OME exists, but age effect is not yet clarified. Pathophysiological association between AR and OME has not been fully understood, but there were several clinical studies. Negative middle ear pressure following nasal allergen challenge in subjects with AR was reported 30 years ago and the involvement of both immunologic and mechanical mechanisms were hypothesized . Gideon et al. tried to prove the pathophysiological mechanisms of OME as Th2 inflammation in the middle ear effusion of atopic individuals, but he hesitated to conclude that allergic inflammation was the cause of OME .
Since there may exist the pathophysiologic associations of AR with OME, treatments targeting allergic inflammation such as antihistamines, LTRA, intranasal corticosteroids or their combination might be useful in the management of OME, before considering surgical intervention .
OME is highly prevalent in children. The hearing loss as a result of OME is a major health issue. Natural defense mechanisms of the upper airway via the epithelial defense barrier and innate immunity protects against environmental insults by microbes. Impairment of these defenses due to allergy may lead to increased susceptibility to infectious organisms in the respiratory tract and middle ear mucosa. In this context, it is known that Toll-like receptor signaling variations are associated with clinical phenotypes and the risk of infection in the middle ear. Allergy not only can induce an inflammatory reaction in the middle ear cavity but also increase susceptibility to infection by microbes. Although allergy plays a crucial role in the etiology of OME there are several other factors that play a role in the etiology of OME. One could hypothesize that as in asthma, there may be different phenotypes of OME, one of these, the most frequent is due to atopy.
Studies to assess precisely the pathogenesis of OME are needed.
Studies to analyze the relation between local environmental allergens and pollutants on OME/EOM in different geographic regions are needed.
Risk factors of OME is are know but studies on interventional strategies to reduce these risk factors and the impact on OME are needed.
Studies evaluating the impact of treatment of allergic rhinitis and rhinosinusitis on OME are needed.
The authors thank the Board of Directors of the World Allergy Organization for supporting the development and distribution of this article.
Availability of data and materials
MEZ conceived the project and co-led the development of the document with RP. MEZ and RP contributed the Abstract, Introduction, and Conclusion and Unmet Needs sections. JSC and HB contributed the sections on Definition, Epidemiology, and Predisposing Factors. JSC and MEZ contributed the sections on Signs, Symptoms, and Diagnosis. RP contributed the section on EOM. YZ and LZ contributed the section on Pathomechanisms and Comorbidities. EH contributed the section on Role of Allergy. NR and MSB contributed the section on Impact of Risk Factors on Disease Severity. YZ and LZ contributed the section on Similarities and Differences. ME and IA contributed the section on Impact of Upper and Lower Airway Inflammation. All authors reviewed and approved the final manuscript.
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- Kenna MA. Otitis Media and the new guidelines. J Otolaryngol. 2005;34(suppl 1):S24–32.Google Scholar
- Luong A, Roland PS. The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. Otolaryngol Clin N Am. 2008;41:311–23.View ArticleGoogle Scholar
- Senturia BS, Bluestone CD, Klein JO, et al. Report or the ad hoc committee on definition and classification of otitis media with effusion. Ann Otol Rhinol Laryngol. 1980;89:3–4.View ArticleGoogle Scholar
- Engel J, Anteunis L, et al. Risk factors of otitis media with effusion during infancy. Int J Pediatr Otorhinolaryngol. 1999;48:239–49.PubMedView ArticleGoogle Scholar
- Elicora SS, Ozturk M, Sevinc R, Derin S, Dinc AE, Erdem D. Risk factors for otitis media effusion in children who have adenoid hypertrophia. Int J Pediatr Otorhinolaryngol. 2015;79(3):374–7.PubMedView ArticleGoogle Scholar
- Alles R, Parish A, Scadding G, et al. The prevalence of atopic disorders in children with chronic otitis media with effusion. Pediatr Allergy Immunol. 2001;12:102–6.PubMedView ArticleGoogle Scholar
- Minovi A, Dazert S. Diseases of the middle ear in childhood. GSM Current Topics in Otorhinolaryngology-Head and Neck Surgery. 2014;13:1–29.Google Scholar
- Roditi RE, Veling M, Shin JJ. Age: an effect modifier of the association between allergic rhinitis and otitis media with effusion. Laryngoscope 2015 (Epub ahead of print).Google Scholar
- Quaranta N, Iannuzzi L, Gelardi M. Does the type of rhinitis influence development of otitis media with effusion in children? Curr Allergy Asthma Rep. 2014;14:472–7.PubMedView ArticleGoogle Scholar
- Kreiner-Moller E, Chawes LK, et al. Allergic rhinitis is associated with otitis media with effusion: a birth cohort study. Clin Exp Allergy. 2012;42:1615–20.PubMedView ArticleGoogle Scholar
- Gravel JS, Wallace IF. Effects of otitis media with effusion on hearing in the first 3 years of life. J Speech Lang Hear Res. 2000 Jun;43(3):631–44.PubMedView ArticleGoogle Scholar
- Madell JR. Impact of otitis media on auditory function. In: Rosenfeld RM, Bluestone CD, editors. Evidence-based otitis media. Canada: B.C. Decker Inc; 1999. p. 337–51.Google Scholar
- Rosenfeld RM, Culpepper L, Doyle KJ, et al. Clinical practice guideline: otitis media with effusion. Otolaryngol Head Neck Surg. 2004 May;130(5 Suppl):S95–118.PubMedView ArticleGoogle Scholar
- Tomioka S, Yuasa R, Iino Y: Intractable otitis media in cases with bronchial asthma. In Recent Advances in Otitis Media: Proceedings of the Second Extraordinary International Symposium on Recent Advances in Otitis Media. Edited by Mogi G, Honjo I, Ishii T, et al.: ).Google Scholar
- Takata GS, Chan LS, Morphew T, et al. Evidence assessment of the accuracy of methods of diagnosing middle ear effusion in children with otitis media with effusion. Pediatrics. 2003;112(6):1379–87.PubMedView ArticleGoogle Scholar
- Tanaka Y, Nonaka M, Yamamura Y, Tagaya E, Pawankar R, Yoshihara T. Improvement of eosinophilic otitis media by optimized asthma treatment. Allergy Asthma Immunol Res. 2013;5(3):175–8.PubMedPubMed CentralView ArticleGoogle Scholar
- Nakagawa T, Matsubara A, Shiratsuchi H, et al. Intractable otitis media with eosinophils: importance of diagnosis and validity of treatment for hearing preservation. ORL J Otorhinolaryngol Relat Spec. 2006;68:118–22.PubMedView ArticleGoogle Scholar
- Haruna S, Yoshikawa M, Otori N, Moriyama H. Relationship between eosinophilic sinusitis and eosinophilic otitis media [in Japanese]. Otol Rhino Laryngol Tokyo. 2003;46:472–80.Google Scholar
- Ferguson BJ. Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope. 2001;119:1670–2.Google Scholar
- Iino Y, Nagamine H, Yabe T, Matsutani S. Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma. Clin Exp Allergy. 2001;31:1135–43.PubMedView ArticleGoogle Scholar
- Nonaka M, Fukumoto A, Ozu C, Pawankar R, et al. IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion. Acta Otolaryngol. 2003;123:383–7.PubMedView ArticleGoogle Scholar
- Iino Y, Kakizaki K, Katano H, et al. Eosinophil chemoattractant in middle ear patients with eosinophilic otitis media. Clin Exp Allergy. 2005;35:1370–6.PubMedView ArticleGoogle Scholar
- Kanazawa H, Yoshida N, Shinnabe A, Iino Y. Antigen-specific IgE in middle ear effusion of patients with eosinophilic otitis media. Ann Allergy Asthma Immunol. 2014;113(1):88–92.PubMedView ArticleGoogle Scholar
- Hurst DS, Amin K, Sevéus L, Venge P. Mast cells and tryptase in the middle ear of children with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 1999;49(Suppl 1):S315–9.PubMedView ArticleGoogle Scholar
- Daly KA, Hoffman HJ, Kvaerner KJ, Kvestad E, Casselbrant ML, Homoe P, et al. Epidemiology, natural history, and risk factors: panel report from the ninth international research conference on otitis media. Int J Pediatr Otorhinolaryngol. 2010;74:231–40.PubMedView ArticleGoogle Scholar
- Caye-Thomasen P, Hermansson A, Bakaletz L, Hellstrom S, Kanzaki S, Kerschner J, et al. Panel 3: recent advances in anatomy, pathology, and cell biology in relation to otitis media pathogenesis. Otolaryngol Head Neck Surg. 2013;148:E37–51.PubMedView ArticleGoogle Scholar
- Martines F, Bentivegna D, Maira E, Sciacca V, Martines E. Risk factors for otitis media with effusion: case-control study in Sicilian schoolchildren. Int J Pediatr Otorhinolaryngol. 2011;75:754–9.PubMedView ArticleGoogle Scholar
- Portmann M. The etiology and pathogenesis of otitis media with effusion. A review Acta Otolaryngol Suppl. 1984;414:41–4.PubMedView ArticleGoogle Scholar
- Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: a review. Clin Otolaryngol Allied Sci. 2000;25:181–94.PubMedView ArticleGoogle Scholar
- Ryding M, White P, Kalm O. Eustachian tube function and tympanic membrane findings after chronic secretory otitis media. Int J Pediatr Otorhinolaryngol. 2004;68:197–204.PubMedView ArticleGoogle Scholar
- Kuo CL, Lien CF, Chu CH, Shiao AS. Otitis media with effusion in children with cleft lip and palate: a narrative review. Int J Pediatr Otorhinolaryngol. 2013;77:1403–9.PubMedView ArticleGoogle Scholar
- Maris M, Wojciechowski M, Van de Heyning P, Boudewyns A. A cross-sectional analysis of otitis media with effusion in children with down syndrome. Eur J Pediatr. 2014;173:1319–25.PubMedView ArticleGoogle Scholar
- Austeng ME, Akre H, Overland B, Abdelnoor M, Falkenberg ES, Kvaerner KJ. Otitis media with effusion in children with in down syndrome. Int J Pediatr Otorhinolaryngol. 2013;77:1329–32.PubMedView ArticleGoogle Scholar
- Mittal R, Kodiyan J, Gerring R, Mathee K, Li JD, Grati M, et al. Role of innate immunity in the pathogenesis of otitis media. Int J Infect Dis. 2014;29:259–67.PubMedView ArticleGoogle Scholar
- Leichtle A, Lai Y, Wollenberg B, Wasserman SI, Ryan AF. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep. 2011;11:78–84.PubMedView ArticleGoogle Scholar
- Chantzi FM, Kafetzis DA, Bairamis T, Avramidou C, Paleologou N, Grimani I, et al. IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion. Allergy. 2006;61:332–6.PubMedView ArticleGoogle Scholar
- Bakaletz LO. Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media. Paediatr Respir Rev. 2012;13:154–9.PubMedPubMed CentralView ArticleGoogle Scholar
- Daniel M, Imtiaz-Umer S, Fergie N, Birchall JP, Bayston R. Bacterial involvement in otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2012;76:1416–22.PubMedView ArticleGoogle Scholar
- Allen EK, Chen WM, Weeks DE, Chen F, Hou X, Mattos JL, et al. A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2. J Assoc Res Otolaryngol. 2013;14:791–800.PubMedPubMed CentralView ArticleGoogle Scholar
- MacArthur CJ, Wilmot B, Wang L, Schuller M, Lighthall J, Trune D. Genetic susceptibility to chronic otitis media with effusion: candidate gene single nucleotide polymorphisms. Laryngoscope. 2014;124:1229–35.PubMedView ArticleGoogle Scholar
- Qureishi A, Lee Y, Belfield K, Birchall JP, Daniel M. Update on otitis media - prevention and treatment. Infect Drug Resist. 2014;7:15–24.PubMedPubMed CentralGoogle Scholar
- Hall-Stoodley L, Hu FZ, Gieseke A, Nistico L, Nguyen D, Hayes J, et al. Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA. 2006;296:202–11.PubMedPubMed CentralView ArticleGoogle Scholar
- Martines F, Martinciglio G, Martines E, Bentivegna D. The role of atopy in otitis media with effusion among primary school children: audiological investigation. Eur Arch Otorhinolaryngol. 2010;267:1673–8.PubMedView ArticleGoogle Scholar
- Hurst DS. The role of allergy in otitis media with effusion. Otolaryngol Clin N Am. 2011;44:637–54. viii-ixView ArticleGoogle Scholar
- Lack G, Caulfield H, Penagos M. The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids. Pediatr Allergy Immunol. 2011;22:258–66.PubMedView ArticleGoogle Scholar
- Luong A, Roland PS. The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. Otolaryngol Clin N Am. 2008;41:311–23. viView ArticleGoogle Scholar
- Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Reflux of gastric juice and glue ear in children. Lancet. 2002;359:493.PubMedView ArticleGoogle Scholar
- Umapathy D, Alles R, Scadding GK. A community based questionnaire study on the association between symptoms suggestive of otitis media with effusion, rhinitis and asthma in primary school children. Int J Pediatr Otorhinolaryngol. 2007;71:705–12.PubMedView ArticleGoogle Scholar
- Caylan R, Bektas D, Atalay C, Korkmaz O. Prevalence and risk factors of otitis media with effusion in Trabzon, a city in northeastern Turkey, with an emphasis on the recommendation of OME screening. Eur Arch Otorhinolaryngol. 2006;263:404–8.PubMedView ArticleGoogle Scholar
- Tong MC, Yue V, Ku PK, Lo PS, Wong EM, van Hasselt CA. Risk factors for otitis media with effusion in Chinese schoolchildren: a nested case-control study and review of the literature. Int J Pediatr Otorhinolaryngol. 2006;70:213–9.PubMedView ArticleGoogle Scholar
- Rovers MM, de Kok IM, Schilder AG. Risk factors for otitis media: an international perspective. Int J Pediatr Otorhinolaryngol. 2006;70:1251–6.28.PubMedView ArticleGoogle Scholar
- Kiris M, Muderris T, Kara T, Bercin S, Cankaya H, Sevil E. Prevalence and risk factors of otitis media with effusion in school children in eastern Anatolia. Int J Pediatr Otorhinolaryngol. 2012;76:1030–5.PubMedView ArticleGoogle Scholar
- Rovers MM, Schilder AG, Zielhuis GA, Rosenfeld RM. Otitis media. Lancet. 2004;363:465–73.PubMedView ArticleGoogle Scholar
- MacArthur CJ, Pillers DA, Pang J, Kempton JB, Trune DR. Altered expression of middle and inner ear cytokines in mouse otitis media. Laryngoscope. 2011;121:365–71.PubMedPubMed CentralView ArticleGoogle Scholar
- Daly KA, Hunter LL, Levine SC, Lindgren BR, Giebink GS. Relationships between otitis media sequelae and age. Laryngoscope. 1998;108:1306–10.PubMedView ArticleGoogle Scholar
- Johnston LC, Feldman HM, Paradise JL, Bernard BS, Colborn DK, Casselbrant ML, et al. Tympanic membrane abnormalities and hearing levels at the ages of 5 and 6 years in relation to persistent otitis media and tympanostomy tube insertion in the first 3 years of life: a prospective study incorporating a randomized clinical trial. Pediatrics. 2004;114:e58–67.PubMedView ArticleGoogle Scholar
- Grevers G. Challenges in reducing the burden of otitis media disease: an ENT perspective on improving management and prospects for prevention. Int J Pediatr Otorhinolaryngol. 2010;74:572–7.PubMedView ArticleGoogle Scholar
- Rosenfeld RM, Kay D. Natural history of untreated otitis media. Laryngoscope. 2003;113:1645–57.PubMedView ArticleGoogle Scholar
- Hardjojo A, Shek LP, van Bever HP, Lee BW. Rhinitis in children less than 6 years of age: current knowledge and challenges. Asia Pac Allergy. 2011;1:115–22.PubMedPubMed CentralView ArticleGoogle Scholar
- Quaranta N, Iannuzzi L, Gelardi M. Does the type of rhinitis influence development of otitis media with effusion in children? Curr Allergy Asthma Rep. 2014;14:472.PubMedView ArticleGoogle Scholar
- Smirnova MG, Birchall JP, Pearson JP. The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion. Mediat Inflamm. 2004;13:75–88.View ArticleGoogle Scholar
- Pelikan Z. Role of nasal allergy in chronic secretory otitis media. Curr Allergy Asthma Rep. 2009;9:107–13.PubMedView ArticleGoogle Scholar
- Marseglia GL, Pagella F, Caimmi D, Caimmi S, Castellazzi AM, Poddighe D, Klersy C, Ciprandi G. Increased risk of otitis media with effusion in allergic children presenting with adenoiditis. Otolaryngol Head Neck Surg. 2008;138:572–5.PubMedView ArticleGoogle Scholar
- Kreiner-Møller E, Chawes BL, Caye-Thomasen P, Bønnelykke K, Bisgaard H. Allergic rhinitis is associated with otitis media with effusion: a birth cohort study. Clin Exp Allergy. 2012;42:1615–20.PubMedView ArticleGoogle Scholar
- Passali D, Passali GC, Lauriello M, Romano A, Bellussi L, Passali FM. Nasal allergy and otitis media: a real correlation? Sultan Qaboos Univ Med J. 2014;14:e59–64.PubMedPubMed CentralView ArticleGoogle Scholar
- Hurst DS, Venge P. Evidence of eosinophil, neutrophil, and mast-cell mediators in the effusion of OME patients with and without atopy. Allergy. 2000;55:435–41.PubMedView ArticleGoogle Scholar
- Zielnik-Jurkiewicz B, Stankiewicz-Szymczak W.Pro-inflammatory interleukins in middle ear effusions from atopic and non-atopic children with chronic otitis media with effusion. Eur Arch Otorhinolaryngol 2015 Jun 16. [Epub ahead of print].Google Scholar
- Williamson I, Benge S, Barton S, Petrou S, Letley L, Fasey N, Abangma G, Dakin H, Little P. A double-blind randomised placebo-controlled trial of topical intranasal corticosteroids in 4- to 11-year-old children with persistent bilateral otitis media with effusion in primary care. Health Technol Assess. 2009;13:1–144.PubMedView ArticleGoogle Scholar
- MacIntyre EA, Chen CM, Herbarth O, Borte M, Schaaf B, Krämer U, von Berg A, Wichmann HE, Heinrich J, LISA Study Group. Early-life otitis media and incident atopic disease at school age in a birth cohort. Pediatr Infect Dis J. 2010;29:e96–9.PubMedView ArticleGoogle Scholar
- Thomson JA, Widjaja C, Darmaputra AA, Lowe A, Matheson MC, Bennett CM, Allen K, Abramson MJ, Hosking C, Hill D, Dharmage SC. Early childhood infections and immunisation and the development of allergic disease in particular asthma in a high-risk cohort: a prospective study of allergy-prone children from birth to six years. Pediatr Allergy Immunol. 2010;21:1076–85.PubMedView ArticleGoogle Scholar
- MacIntyre EA, Heinrich J. Otitis media in infancy and the development of asthma and atopic disease. Curr Allergy Asthma Rep. 2012;12:547–50.PubMedView ArticleGoogle Scholar
- Kwon C, Lee HY, Kim MG, Boo SH, Yeo SG. Allergic diseases in children with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2013;77:158–61.PubMedView ArticleGoogle Scholar
- Bernstein JM, Lee J, Conboy K, Ellis E, Li P. Further observations on the role of IgE-mediated hypersensivity in recurrent otitis media with effusion. Otolaryngol Head Neck Surg. 1985;93:611–5.PubMedView ArticleGoogle Scholar
- Becker S, Koch T, Philipp A. Allergic origin of recurrent middle ear effusion and adenoids in young children. HNO. 1991;39:182–4.PubMedGoogle Scholar
- Corey JP, Adham RE, Abbass AH, Seligman I. The role of IgE-mediated hypersensivity in otitis media with effusion. Am J Otolaryngol. 1994;15:138–44.PubMedView ArticleGoogle Scholar
- Zhang Y, Xu M, Zhang J, Zeng L, Wang Y, Zheng QY. Risk factors for chronic and recurrent otitis media–a meta-analysis. PLoS One. 2014;9:e86397.PubMedPubMed CentralView ArticleGoogle Scholar
- Kırıs M, Muderris T, Kara T, Bercin S, Cankaya H, Sevil E. Prevalence and risk factors of otitis media with effusion in school children in eastern Anatolia. Int J Pediatr Otorhinolaryngol. 2012;76:1030–5.PubMedView ArticleGoogle Scholar
- Chantzi FM, Kafetzis DA, Bairamis T, Avramidou C, Paleologou N, Grimani I, Apostolopoulos N, Papadopoulos NG. IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion. Allergy. 2006;61:332–6.PubMedView ArticleGoogle Scholar
- Nguyen LHP, Manoukian JJ, Sobol SE, et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol. 2004;114:1110–5.PubMedView ArticleGoogle Scholar
- Döner F, Yariktas M, Demirci M. The role of allergy in recurrent otitis media with effusion. J Investig Allergol Clin Immunol. 2004;14:154–8.PubMedGoogle Scholar
- Tracy JM, Demain JG, Hoffman KM, Goetz DW. Intranasal beclomethasone as an adjunct to treatment of chronic middle ear effusion. Ann Allergy Asthma Immunol. 1998;80:198–206.PubMedView ArticleGoogle Scholar
- Mandel EM, Casselbrant ML, Rockette HE, Fireman P, Kurs-Lasky M, Bluestone CD. Systemic steroid for chronic otitis media with effusion in children. Pediatrics. 2002;110:1071–80.PubMedView ArticleGoogle Scholar
- Nsouli TM, Nsouli SM, Linde RE, O’Mara F, Scanlon RT, Bellanti JA. Role of food allergy in serous otitis media. Ann Allergy. 1994;73:215–9.PubMedGoogle Scholar
- Juntti H, Tikkanen S, Kokkonen J, Alho OP, Niinimäki A. Cow’s milk allergy is associated with recurrent otitis media during childhood. Acta Otolaryngol. 1999;119:867–73.PubMedView ArticleGoogle Scholar
- Ramakrishnan JB. The role of food allergy in otolaryngology disorders. Curr Opin Otolaryngol Head Neck Surg. 2010;18:195–9.PubMedView ArticleGoogle Scholar
- Kanazawa H, Yoshida N, Shinnabe A, Iino Y. Antigen-specific IgE in middle ear effusion of patients with eosinophilic otitis media. Ann Allergy Asthma Immunol. 2014;113:88–92.PubMedView ArticleGoogle Scholar
- Iino Y. Role of IgE in eosinophilic otitis media. Allergol Int. 2010;59:233–8.PubMedView ArticleGoogle Scholar
- Tanaka Y, Nonaka M, Yamamura Y, Tagaya E, Pawankar R, Yoshihara T. Improvement of eosinophilic otitis media by optimized asthma treatment. Allergy Asthma Immunol Res. 2013;5:175–8.PubMedPubMed CentralView ArticleGoogle Scholar
- Okude A, Tagaya E, Kondo M, Nonaka M, Tamaoki J. A case of severe asthma with eosinophilic otitis media successfully treated with anti-IgE monoclonal antibody omalizumab. Case Rep Pulmonol. 2012;2012:340525.PubMedPubMed CentralGoogle Scholar
- Tomonaga K, Kurono Y, Mogi G. The role of nasal allergy in otitis media with effusion. A clinical study. Acta Otolaryngol Suppl. 1988;458:41–7.PubMedView ArticleGoogle Scholar
- Irander K, Borres MP, Bjorksten B. Middle ear diseases in relation to atopy and nasal metachromatic cells in infancy. Int J Pediatr Otorhinolaryngol. 1993;26:1–9.PubMedView ArticleGoogle Scholar
- Stenstrom C, Ingvarsson L. General illness and need of medical care in otitis prone children. Int J Pediatr Otorhinolaryngol. 1994;29:23–32.PubMedView ArticleGoogle Scholar
- Kreiner-Moller E, Chawes BL, Caye-Thomasen P, Bonnelykke K, Bisgaard H. Allergic rhinitis is associated with otitis media with effusion: a birth cohort study. Clin Exp Allergy. 2012;42:1615–20.PubMedView ArticleGoogle Scholar
- Takeuchi K, Fujita Y, Tomemori T, Yuta A, Iriyoshi N, Sakakura Y. Analysis of T cell receptor beta chain repertoire in middle ear effusions. Ann Otol Rhinol Laryngol. 1996;105:213–7.PubMedView ArticleGoogle Scholar
- Krouse JH. The unified airway--conceptual framework. Otolaryngol Clin N Am. 2008;41:257–66. vView ArticleGoogle Scholar
- Braunstahl GJ, Overbeek SE, Kleinjan A, Prins JB, Hoogsteden HC, Fokkens WJ. Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways. J Allergy Clin Immunol. 2001;107:469–76.PubMedView ArticleGoogle Scholar
- Grossman J. One airway, one disease. Chest. 1997;111:11S–6S.PubMedView ArticleGoogle Scholar
- Nguyen LH, Manoukian JJ, Sobol SE, Tewfik TL, Mazer BD, Schloss MD, et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol. 2004;114:1110–5.PubMedView ArticleGoogle Scholar
- Parietti-Winkler C, Baumann C, Gallet P, Gauchard G, Jankowski R. Otitis media with effusion as a marker of the inflammatory process associated to nasal polyposis. Rhinology. 2009;47:396–9.PubMedGoogle Scholar
- Parietti-Winkler C, Jankowski R. Is there an association between otitis media and nasal polyposis? Curr Allergy Asthma Rep. 2011;11:521–5.PubMedView ArticleGoogle Scholar
- Ichimiya I, Kawauchi H, Mogi G. Analysis of immunocompetent cells in the middle ear mucosa. Arch Otolaryngol Head Neck Surg. 1990;116:324–30.PubMedView ArticleGoogle Scholar
- Iino Y, Usubuchi H, Kodama K, Kanazawa H, Takizawa K, Kanazawa T, et al. Eosinophilic inflammation in the middle ear induces deterioration of bone-conduction hearing level in patients with eosinophilic otitis media. Otol Neurotol. 2010;31:100–4.PubMedView ArticleGoogle Scholar
- De Schryver E, Devuyst L, Derycke L, Dullaers M, Van Zele T, Bachert C, et al. Local immunoglobulin e in the nasal mucosa: clinical implications. Allergy Asthma Immunol Res. 2015;7:321–31.PubMedPubMed CentralView ArticleGoogle Scholar
- Bachert C, Gevaert P, Holtappels G, Johansson SG, van Cauwenberge P. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol. 2001;107:607–14.PubMedView ArticleGoogle Scholar
- Roditi RE, Veling M, Shin JJ. Age: An effect modifier of the association between allergic rhinitis and otitis media with effusion. Laryngoscope. 2015; Published online ahead of print, (30 September). doi:10.1002/lary.25682.
- Midgley EJ, Dewey C, Pryce K, Maw AR, Study Team ALSPAC. The frequency of otitis media with effusion in British pre-school children: a guide for treatment. Clin Otolaryngol Allied Sci. 2000;25:485–91.PubMedView ArticleGoogle Scholar
- O’Connor RD, Ort H, Leong AB, Cook DA, Street D, Hamburger RN. Tympanometric changes following nasal antigen challenge in children with allergic rhinitis. Ann Allergy. 1984;53:468–71.PubMedGoogle Scholar
- Lack G, Caulfield H. Penagos M the link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids. Pediatr Allergy Immunol. 2011;22:258–66.PubMedView ArticleGoogle Scholar
- American Academy of Family Physicians, American Academy of Otolaryngology-Head and Neck Surgery and American Academy of Pediatrics, Subcommittee on Otitis Media With Effusion. Otitis media with effusion: clinical practice guideline. Pediatrics. 2004;113:1412–29.View ArticleGoogle Scholar