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Table 1 Demographic and disease characteristics

From: Omalizumab in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA): single-center experience in 18 cases

Patient/ sex/ Age Duration of asthma (yr) Duration of EGPA(yr) Total IgE kU/L Eosinophil cells/mm3, (%) Radiologic Findings Vasculitis Polyeuropathy Cardiac involvement ANCA Azathioprine Omalizumab
Dose (mg) / treatment duration (m)
Response
Paranasal CT Torax CT
1.F/63 27 8 46.9 1700 (21.5) Pansinusitis Migratory ground glass opacities, bronchial wall thickness bronchiectasis No No No Neg No 150/m/48 m Complete
2.F/25 5 4 865 1800 (20.2) Pansinusitis, nasal polyposis Ground glass opacities, bronchial wall thickness No No No Neg No 450/2w/15 m
Stopped
None
3.F/52 24 21 11.8 13,480 (60) Fronthoetmoid sinusitis, nasal polyposis Ground glass opacities, bronchial wall thickness Yes No No Neg No 150/m/18 m
Stopped
None
4.F/44 11 8 47.9 3300 (27) Pansinusitis Transient ground glass opacities, bronchial wall thickness, milimetric nodules No No No Neg No 150/m/44 m Complete
5.F/47 12 4 134 1000 (15.9) Pansinusitis Ground glass opacities Yes No No Neg No 300/m/39 m Complete
6.F/67 22 8 17.8 8400 (53) Pansinusitis Transient ground glass opacities, milmetric nodules No Yes No Pos No 150/m/62 m Complete
7.F/62 19 4 114 1200 (20.3) Pansinusitis Transient ground glass opacities, bronchial wall thickness, mucous impactions No No No Neg No 150/m/48 m Complete
8.M/36 7 7 108 2900 (26) Pansinusitis Peribronchial thickness, ground glass opacities dominant at left upper lobe, focal patchy infiltrations No No No Neg No 150/m/48 m Complete
9.F/50 10 10 41 2500 (24.9) Maxiller sinusitis, nasal poliposis Mucous impaction, bronchial wall thickness, bronchiectasis Yes Yes Yes Neg Yes 150/m/42 m None
10.F/40 11 8 142 1100 (14) Pansinusitis Subpleural ground glass opacification, pulmonary nodules Yes No No Neg Yes 150/m/60 m Partial
11.F/52 19 3.5 543 13,600 (52.4) Nasal poliposis Bronchial wall thickness, sublobuler patchy infiltrations No No No Pos No 600/m/27 m None
12.M/38 17 11 126 8900 (47.5) Pansinusitis Paranchimal nodules, bronchial wall thickness Yes No No Neg No 300/m/70 m Complete
13.F/61 36 7 186 2700 (20.7) Pansinusitis Migratory ground glass opasities, nodules and mucus impaction Yes No No Neg No 300/m/64 m None
14.F/45 21 8 321 2200 (21.5) Chronic sinusitis Bilateral bronchial wall thickness Yes Yes No Neg Yes 300/2w/14 m
Stopped
None
15.F/46 22 4 46 3800 (28.8) Frontoetmoid sinusitis, nasal polipozis Transient ground glass opacities No Yes No Neg No 150/m/18 m Complete
16.F/37 9 5 87.5 2700 (36.5) Pansinusitis, nasal polyposis Transient ground glass opacities No No No Neg Yes 150/m/20 m None
17.F/50 12 12 29 5070 (35.9) Pan sinusitis Bronchial wall thickness No No Yes Neg No 150/m/17 m
Stopped
Complete
18.F/28 5 2 71 1440 (15.1) Pansinusitis Peribronchioler ground glass opasities, micronodules Yes No No Neg Yes 150/m/18 m Complete