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Table 4 Blood parameters of subjects according to their clinical benefit after treatment

From: Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study

Hematology Before SLIT After SLIT Absolute change (after-before)  
no benefit, n = 15 clinical benefit, n = 26   no benefit, n = 15 clinical benefit, n = 26   no benefit, n = 15 clinical benefit, n = 26  
Median (Min, Max) Median (Min, Max) t-test Median (Min, Max) Median (Min, Max) t-test Median (Min, Max) Median (Min, Max) t-test
red blood cell count [10A12/L] 4.6 (4, 5.3) 4.6 (3.9, 5.3) 0.773 4.8 (3.8, 5,6) 4.7 (3.8, 5.5) 0.663 0.2 (−0.4, 0.6) 0.1 (−0.5, 0.4) 0.297
hematocrit 0.432 (0.349, 0.487) 0.429 (0.376, 0.482) 0.699 0.437 (0.367, 0.509) 0.433 (0.363, 0.507) 0.886 0.016 (−0.036, 0.052 0.013 (−0.041, 0.034) 0.586
hemoglobin [g/L] 144 (111, 171) 142 (125, 162) 0.735 145 (113, 169) 139 (114, 167) 0.943 0 (−15, 14) 0.5 (−18, 7) 0.716
platelete count [10A9/L] 268 (164, 381) 229 (168, 373) 0.225 243 (155, 378) 231 (177, 361) 0.460 −5 (−107, 104) 2.5 (−71, 36) 0.670
white cell count [10A9 /L] 5.55 (3.7, 15.2) 5.7 (3.1, 12.3) 0.706 6.1 (4.3, 12.5) 6.1 (4.3, 10.9) 0.795 0.9 (−9.4, 4.1) 0.25 (−4, 3.8) 0.853
basophils abs [10A9/L] 0.025(0.01, 0.05) 0.02 (0, 0.08) 0.975 0.03 (0.01, 0.05) 0.03 (0, 0.07) 0.524 0 (−0.02, 0.03) 0 (−0.02, 0.02) 0.442
basophils [%] 0.35 (0.2, 1,1) 0.5 (0.1, 1.1) 0.731 0.5 (0.2, 1) 0.5 (0.1, 0.8) 0.453 0 (−0.6, 0.7) 0 (−0.6, 0,5) 0.438
eosinophils abs [10A9/L] 0.15 (0, 0.42) 0.13 (0.04, 1.26) 0.559 0.25 (0.07, 0.5) 0.245 (0.12, 0.47) 0.965 0.08 (−0.04, 0.27) 0.09 (−0.8, 0.37) 0.569
eosinophils [%] 2.65 (0.1, 6.2) 2.3 (0.5, 21.5) 0.604 4.2 (1.2, 9.7) 4.2 (1.7, 7.9) 0.846 1.5 (−2, 4.2) 1.25 (−13.6, 5.5) 0.551
lymphocytes abs [10A9/L] 1.67 (1.19, 2.56) 1.76 (1.11, 3.03) 0.407 2.43 (1.71, 3.56) 2.17 (1.43, 4.43) 0.463 0.59 (0.05, 1.92) 0.43 (−0.38, 1.4) 0.082
lymphocytes [%] 29.9 (9.9, 41) 30.6 (19.1, 47.9) 0.393 38.7 (16.8, 57.8) 36.9 (23.3, 50.7) 0.323 7.9 (−4.1, 21.8) 3.95 (−8.9, 18.5) 0.043
monocytes abs [10A9/L] 0.375 (0.15, 0.62) 0.31 (0.23, 0.89) 0.936 0.39 (0.3, 0.89) 0.385 (0.21, 0.71) 0.499 0.01 (−0.14, 0.35) 0.04 (− 0.47, 0.32) 0.603
monocytes [%] 6.5 (2.4, 10.4) 5.6 (4.1, 9) 0.742 6.5 (4.7, 9.7) 6.45 (3.8, 11.8) 0.603 0.3 (−4.5, 4.2) 0.8 (−5.2, 3.6) 0.926
neutrophils abs [10A9/L] 3.34 (1.92, 13.18) 3.33 (1.4, 8.9) 0.526 3.18 (1.61, 9.14) 3.57 (1.63, 6.38) 0.929 0.15 (−9.71, 3.15) 0.04 (−4.87, 2.72) 0.476
neutrophils [%] 60.4 (49.7, 86.9) 58.9 (41, 72.8) 0.392 50.6 (32.2, 73) 51.4 (35.9, 68,3) 0.301 −8.4 (−26.8, 1.6) −5.25 (−24, 12.2) 0.043
protein in serum [g/L] 73 (66, 80) 73 (66, 79) 0.869 76 (67, 78) 74 (65, 83) 0.866 1 (−7, 6) 1 (−5, 9) 0.767
albumin [g/L] 48 (43, 55) 48 (42, 53) 0.830 47 (43, 55) 48 (39, 53) 0.768 0 (−6, 8) 0 (−5, 6) 0.914
calcium [mmol/L] 2.46 (2.31, 2.73) 2.47 (2.3, 2.57) 0.477 2.42 (2.28, 2.64) 2.46 (2.24, 2.58) 0.874 −0.01 (−0.31, 0.14) −0.01 (−0,16, 0.19) 0.314
phosphor inorganic [mmol/L] 1.08 (0.8, 1.57) 1.17 (0.82, 1.3) 0.677 1.24 (1.01, 1.51) 1.21 (0.89, 1.54) 0.407 0.19 (−0.36, 0.43) 0.14 (−0.26, 0.41) 0.431
urea nitrogen [mmol/L] 4.4 (2.6, 7.8) 4.6 (2.4, 7.3) 0.783 4.7 (3.3, 6.3) 4.9 (3, 7.1) 0.767 0.3 (−1.6, 2.8) 0.2 (−2.4, 3) 0.835
bilirubin [umol/L] 9.5 (5, 16) 10 (4, 35) 0.205 8 (4, 13) 8 (4, 25) 0.064 −2 (−9, 5) −1 (− 12, 8) 0.898
alkaline phosphatase [U/L] 57 (43, 74) 64 (31, 92) 0.253 59 (47, 94) 70 (29, 104) 0.369 2 (−12, 38) 4 (−8, 33) 0.918
ASAT (SGOT) [U/L] 20.5 (15,40) 19 (16, 29) 0.394 20 (12, 36) 18 (13, 30) 0.055 0 (−6, 15) −1 (−9, 8) 0.211
ALAT (SGPT) [U/L] 12 (6, 48) 13 (7, 34) 0.584 15 (7, 46) 13 (7, 50) 0.134 1 (−11, 40) 0 (−14, 20) 0.277
lactic dehydrogenase [U/L] 157 (113, 200) 148 (111, 178) 0.141 159 (115, 188) 146 (116, 184) 0.640 0 (−34, 22) 5 (−16, 26) 0.137
creatinine [umol/L] 71.6 (59.8, 113.4) 75.9 (56.8, 101.4) 0.588 70.7 (60.7, 113.3) 72.5 (57.5, 103.1) 0.845 −2.2 (−7.7, 12.1) 1.1 (−34, 11.3) 0.662
glucose [mmol/L] 4.8 (3.7, 6) 5 (3.8, 5.8) 0.261 4.9 (3.7, 12.1) 4.9 (3.4, 7.9) 0.281 0.7 (−0.7, 6.1) −0.1 (−1.3, 2.9) 0.062
potassium [mmol/L] 4.55 (3.9, 5.2) 4.4 (3.8, 5.1) 0.014 4.4 (3.9, 5.4) 4.2 (3.9, 4.9) 0.045 −0.2 (− 0.9, 1) −0.1 (− 0.5, 0.5) 0.512
sodium [mmol/L] 139 (137, 144) 140 (137, 141) 0.975 140 (137, 141) 139 (137, 145) 0.699 −1 (−4, 3) 0 (− 1, 4) 0.782
chloride [mmol/L] 103 (100, 106) 104 (101, 106) 0.832 104 (98, 106) 104 (100, 109) 0.768 2 (−5, 4) 1 (− 4, 5) 0.958
carbon dioxide, CO2 [mmol/L] 21 (17, 24) 22 (17, 25) 0.388 23 (18, 26) 22 (18, 25) 0.183 1 (−3 7) 0 (−6, 6) 0.183