Hematology | Before SLIT | T-test | After SLIT | t-test | Absolute change (after-before) | Â | |||
---|---|---|---|---|---|---|---|---|---|
Placebo, n = 10 | Active, n = 31 | Placebo, n = 10 | Active, n = 31 | Placebo, n = 10 | Active, n = 31 |  | |||
Median (Min, Max) | Median (Min, Max) | Median (Min, Max) | Median (Min, Max) | Median (Min, Max) | Median (Min, Max) | t-test | |||
red blood cell count [10″ 12/L] | 4.9 (4, 5.3) | 4.5 (3.9, 5.3) | 0.190 | 5.2 (4.3, 5.6) | 4.55 (3.8, 5.5) | 0.017 | 0.3 (−0.4, 0.6) | 0.100 (− 0.5, 0.4) | 0.062 |
hematocrit | 0.441 (0.363, 0.487) 0.424 (0.349, 0.484) | 0.379 | 0.47 (0.367,0.509) | 0.429 (0.363,0.507) | 0.131 | 3.026 (−0.036,0.052)0.013 (− 0.041,0.037) | 0.367 | ||
hemoglobin [g/L] | 148 (113, 161) | 141 (111, 171 | 0.458 | 149 (113, 169) | 139 (114, 167) | 0.136 | 2 (−15, 14) | -1 (−18,8) | 0.299 |
platelete count [10A9/L] | 259 (164, 329) | 229 (168, 381) | 0.582 | 242 (159, 378) | 235 (155, 361) | 0.532 | 5 (−107, 104) | 2 (−96, 62) | 0.635 |
white cell count [10A9 /L] | 5.75 (3.7, 15.2) | 5.7 (3.1, 12.3) | 0.465 | 6.4 (5.3, 9.3) | 6 (4.3, 12.5) | 0.763 | 1.1 (−9.4, 2.7) | 0.3 (−4, 4.1) | 0.579 |
basophils abs [10A9/L] | 0.02 (0.01,0.05) | 0.03 (0, 0.08) | 0.413 | 0.03 (0,0.05) | 0.03 (0.01,0.07) | 0.530 | 0 (−0.02, 0.03) | 0.00 (− 0.02, 0.03) | 0.768 |
basophils [%] | 0.3 (0.2, 1.1) | 0.5 (0.1, 1.1) | 0.359 | 0.5 (0.1, 0.6) | 0.5 (0.2, 1) | 0.467 | 0.1 (−0.6, 0.3) | 0.0 (−0.6, 0.7) | 0.920 |
eosinophils abs [10A9/L] | 0.09 (0, 0.3) | 0.14 (0.04, 1.26) | 0.215 | 0.22 (0.07, 0.47) | 0.25 (0.12, 0.5) | 0.578 | 0.11 (−0.03,0.37) | 0.09 (−0.8, 0.33) | 0.357 |
eosinophils [%] | 2 (0.1, 4) | 2.5 (0.5,21.5) | 0.245 | 3.5 (1.2, 7) | 4.25 (1.7, 9.7) | 0.304 | 1.5 (−2,5.5) | 1.25 (−13.6,4.2) | 0.615 |
lymphocytes abs [10A9/L] | 1.66 (1.19,2.56) | 1.73 (1.11,3.03) | 0.727 | 2.77 (1.83, 3.56) | 2.15 (1.43, 4.43) | 0.114 | 0.97 (0.04, 1.92) | 0.43 (−0.38, 1.4) | 0.019 |
lymphocytes [%] | 29.8 (9.9, 41) | 30.6 (19.1,47.9) | 0.573 | 38.7 (29.6, 57.8) | 37.2 (16.8, 50.7) | 0.204 | 10.1 (−0.4,21.8) | 3.85 (−8.9, 18.6) | 0.052 |
monocytes abs [10 A9/L] | 0.345 (0.22, 0.62) | 0.32 (0.15, 0.89) | 0.911 | 0.39 (0.37, 0.6) | 0.38 (0.21,0.89) | 0.652 | 0.04 (−0.07,0.32) | 0.03 (−0.47, 0.35) | 0.632 |
monocytes [%] | 5.7 (2.9, 10) | 5.7 (2.4, 10.4) | 0.852 | 6.4 (4.7, 9.7) | 6.55 (3.8, 11.8) | 0.744 | 0.3 (−2.2, 3.6) | 0.6 (−5.2, 4.2) | 0.745 |
neutrophils abs [10A9/L] | 3.55 (1.92, 13.18) | 3.33 (1.4, 8.93) | 0.310 | 3.32 (1.7,5.41) | 3.31 (1.61,9.14) | 0.752 | 0.22 (−9.71,0.8) | 0.04 (−4.87, 3.15) | 0.199 |
neutrophils [%] | 62.1 (49.7,86.9) | 58.9 (41,72.8) | 0.343 | 53.3 (32.2, 60.1) | 50.6 (34.4, 73) | 0.330 | −8.5 (−26.8,-5.8) | −5.15 (− 24.6, 12.2) | 0.050 |
protein in serum [g/L] | 72 (69, 80) | 74 (66, 79) | 0.846 | 76 (68, 78) | 74 (65, 83) | 0.686 | 1 (−7,6) | 1 (− 7, 9) | 0.747 |
albumin [g/L] | 48.5 (44, 55) | 48 (42, 53) | 0.567 | 52 (43, 55) | 48 (39, 53) | 0.182 | 0 (−6, 8) | 0 (−5, 6) | 0.515 |
calcium [mmol/L] | 2.49 (2.31,2.57) | 2.45 (2.3, 2.73) | 0.862 | 2.42 (2.34, 2.64) | 2.45 (2.24, 2.58) | 0.786 | −0.03 (−0.16, 0.14) | −0.01 (−0.31,0.19) | 0.812 |
phosphor inorganic [mmol/L] | 1.08 (0.83, 1.57) | 1.14 (0.8, 1.3) | 0.772 | 1.24 (1.01, 1.47) | 1.21 (0.89, 1.54) | 0.502 | 0.19 (−0.36,0.41) | 0.15 (−0.26, 0.43) | 0.962 |
urea nitrogen [mmol/L] | 4.5 (3.5, 7.5) | 4.4 (2.4, 7.8) | 0.631 | 5.5 (4.4, 6.3) | 4.7 (3,7.1) | 0.112 | 0.3 (−1.5, 2.8) | 0.2 (−2.4, 3) | 0.678 |
bilirubin [umol/L] | 10 (5,20) | 10 (4, 35) | 0.582 | 8 (5, 10) | 8 (4, 25) | 0.123 | 0 (−12, 2) | −1 (− 10,8) | 0.397 |
alkaline phosphatase [U/L] | 55 (43, 69) | 62 (31,92) | 0.264 | 60 (47, 86) | 65 (29, 104) | 0.430 | 4 (−12, 34) | 3 (−8, 38) | 0.843 |
AS AT (SGOT) [U/L] | 20 (15, 30) | 20 (16, 40) | 0.710 | 20 (12, 36) | 19 (13, 35) | 0.518 | 1 (−5, 15) | −1 (−9, 10) | 0.240 |
ALAT (SGPT) [U/L] | 12 (7,39) | 13 (6, 48) | 0.836 | 14 (7,39) | 13 (7,50) | 0.635 | 2 (−4, 24) | −1 (− 14,40) | 0.522 |
lactic dehydrogenase [U/L] | 157 (113,200) | 148 (111, 178) | 0.147 | 160 (115, 188) | 146 (116, 184) | 0.472 | 2 (−34, 22) | 5 (−16, 26) | 0.224 |
creatinine [umol/L] | 72.6 (65.9, 96.5) | 74.3 (56.8, 113.4) | 0.599 | 72 (63.8, 103.1) | 71.7 (57.5, 113.3) | 0.987 | −2.2 (−7.7, 12.1) | −0.1 (− 34, 11.3) | 0.500 |
glucose [mmol/L] | 4.9 (3.8, 5.8) | 5 (3.7, 6) | 0.728 | 4.8 (3.4, 5.7) | 4.9 (3.9, 12.1) | 0.317 | −0.2 (−1.2, 1) | 0.2 (− 1.3, 6.1) | 0.480 |
potassium [mmol/L] | 4.45 (4.1, 5.2) | 4.4 (3.8, 5.1) | 0.158 | 4.3 (3.9, 5.4) | 4.3 (3.9, 5.1) | 0.491 | −0.2 (−0.9, 1) | − 0.1 (− 0.5, 0.5) | 0.392 |
sodium [mmol/L] | 140 (138, 142) | 140 (137, 144) | 0.111 | 140 (137, 145) | 139 (137, 142) | 0.069 | −1 (−3, 4) | 0 (−4, 3) | 0.814 |
chloride [mmol/L] | 104 (101, 106) | 103 (100, 106) | 0.275 | 104 (98, 109) | 104 (98, 108) | 0.733 | 0 (−4, 5) | 1 (−5, 4) | 0.952 |
carbon dioxide, C02 [mmol/L] | 21 (17, 24) | 21 (17, 25) | 0.496 | 23 (18, 26) | 22 (18, 25) | 0.077 | 2 (−3,7) | 0 (−6, 6) | 0.158 |