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Table 2 Blood parameters in placebo and active SLIT groups and their absolute change

From: Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study

Hematology

Before SLIT

T-test

After SLIT

t-test

Absolute change (after-before)

 

Placebo, n = 10

Active, n = 31

Placebo, n = 10

Active, n = 31

Placebo, n = 10

Active, n = 31

 

Median (Min, Max)

Median (Min, Max)

Median (Min, Max)

Median (Min, Max)

Median (Min, Max)

Median (Min, Max)

t-test

red blood cell count [10″ 12/L]

4.9 (4, 5.3)

4.5 (3.9, 5.3)

0.190

5.2 (4.3, 5.6)

4.55 (3.8, 5.5)

0.017

0.3 (−0.4, 0.6)

0.100 (− 0.5, 0.4)

0.062

hematocrit

0.441 (0.363, 0.487) 0.424 (0.349, 0.484)

0.379

0.47 (0.367,0.509)

0.429 (0.363,0.507)

0.131

3.026 (−0.036,0.052)0.013 (− 0.041,0.037)

0.367

hemoglobin [g/L]

148 (113, 161)

141 (111, 171

0.458

149 (113, 169)

139 (114, 167)

0.136

2 (−15, 14)

-1 (−18,8)

0.299

platelete count [10A9/L]

259 (164, 329)

229 (168, 381)

0.582

242 (159, 378)

235 (155, 361)

0.532

5 (−107, 104)

2 (−96, 62)

0.635

white cell count [10A9 /L]

5.75 (3.7, 15.2)

5.7 (3.1, 12.3)

0.465

6.4 (5.3, 9.3)

6 (4.3, 12.5)

0.763

1.1 (−9.4, 2.7)

0.3 (−4, 4.1)

0.579

basophils abs [10A9/L]

0.02 (0.01,0.05)

0.03 (0, 0.08)

0.413

0.03 (0,0.05)

0.03 (0.01,0.07)

0.530

0 (−0.02, 0.03)

0.00 (− 0.02, 0.03)

0.768

basophils [%]

0.3 (0.2, 1.1)

0.5 (0.1, 1.1)

0.359

0.5 (0.1, 0.6)

0.5 (0.2, 1)

0.467

0.1 (−0.6, 0.3)

0.0 (−0.6, 0.7)

0.920

eosinophils abs [10A9/L]

0.09 (0, 0.3)

0.14 (0.04, 1.26)

0.215

0.22 (0.07, 0.47)

0.25 (0.12, 0.5)

0.578

0.11 (−0.03,0.37)

0.09 (−0.8, 0.33)

0.357

eosinophils [%]

2 (0.1, 4)

2.5 (0.5,21.5)

0.245

3.5 (1.2, 7)

4.25 (1.7, 9.7)

0.304

1.5 (−2,5.5)

1.25 (−13.6,4.2)

0.615

lymphocytes abs [10A9/L]

1.66 (1.19,2.56)

1.73 (1.11,3.03)

0.727

2.77 (1.83, 3.56)

2.15 (1.43, 4.43)

0.114

0.97 (0.04, 1.92)

0.43 (−0.38, 1.4)

0.019

lymphocytes [%]

29.8 (9.9, 41)

30.6 (19.1,47.9)

0.573

38.7 (29.6, 57.8)

37.2 (16.8, 50.7)

0.204

10.1 (−0.4,21.8)

3.85 (−8.9, 18.6)

0.052

monocytes abs [10 A9/L]

0.345 (0.22, 0.62)

0.32 (0.15, 0.89)

0.911

0.39 (0.37, 0.6)

0.38 (0.21,0.89)

0.652

0.04 (−0.07,0.32)

0.03 (−0.47, 0.35)

0.632

monocytes [%]

5.7 (2.9, 10)

5.7 (2.4, 10.4)

0.852

6.4 (4.7, 9.7)

6.55 (3.8, 11.8)

0.744

0.3 (−2.2, 3.6)

0.6 (−5.2, 4.2)

0.745

neutrophils abs [10A9/L]

3.55 (1.92, 13.18)

3.33 (1.4, 8.93)

0.310

3.32 (1.7,5.41)

3.31 (1.61,9.14)

0.752

0.22 (−9.71,0.8)

0.04 (−4.87, 3.15)

0.199

neutrophils [%]

62.1 (49.7,86.9)

58.9 (41,72.8)

0.343

53.3 (32.2, 60.1)

50.6 (34.4, 73)

0.330

−8.5 (−26.8,-5.8)

−5.15 (− 24.6, 12.2)

0.050

protein in serum [g/L]

72 (69, 80)

74 (66, 79)

0.846

76 (68, 78)

74 (65, 83)

0.686

1 (−7,6)

1 (− 7, 9)

0.747

albumin [g/L]

48.5 (44, 55)

48 (42, 53)

0.567

52 (43, 55)

48 (39, 53)

0.182

0 (−6, 8)

0 (−5, 6)

0.515

calcium [mmol/L]

2.49 (2.31,2.57)

2.45 (2.3, 2.73)

0.862

2.42 (2.34, 2.64)

2.45 (2.24, 2.58)

0.786

−0.03 (−0.16, 0.14)

−0.01 (−0.31,0.19)

0.812

phosphor inorganic [mmol/L]

1.08 (0.83, 1.57)

1.14 (0.8, 1.3)

0.772

1.24 (1.01, 1.47)

1.21 (0.89, 1.54)

0.502

0.19 (−0.36,0.41)

0.15 (−0.26, 0.43)

0.962

urea nitrogen [mmol/L]

4.5 (3.5, 7.5)

4.4 (2.4, 7.8)

0.631

5.5 (4.4, 6.3)

4.7 (3,7.1)

0.112

0.3 (−1.5, 2.8)

0.2 (−2.4, 3)

0.678

bilirubin [umol/L]

10 (5,20)

10 (4, 35)

0.582

8 (5, 10)

8 (4, 25)

0.123

0 (−12, 2)

−1 (− 10,8)

0.397

alkaline phosphatase [U/L]

55 (43, 69)

62 (31,92)

0.264

60 (47, 86)

65 (29, 104)

0.430

4 (−12, 34)

3 (−8, 38)

0.843

AS AT (SGOT) [U/L]

20 (15, 30)

20 (16, 40)

0.710

20 (12, 36)

19 (13, 35)

0.518

1 (−5, 15)

−1 (−9, 10)

0.240

ALAT (SGPT) [U/L]

12 (7,39)

13 (6, 48)

0.836

14 (7,39)

13 (7,50)

0.635

2 (−4, 24)

−1 (− 14,40)

0.522

lactic dehydrogenase [U/L]

157 (113,200)

148 (111, 178)

0.147

160 (115, 188)

146 (116, 184)

0.472

2 (−34, 22)

5 (−16, 26)

0.224

creatinine [umol/L]

72.6 (65.9, 96.5)

74.3 (56.8, 113.4)

0.599

72 (63.8, 103.1)

71.7 (57.5, 113.3)

0.987

−2.2 (−7.7, 12.1)

−0.1 (− 34, 11.3)

0.500

glucose [mmol/L]

4.9 (3.8, 5.8)

5 (3.7, 6)

0.728

4.8 (3.4, 5.7)

4.9 (3.9, 12.1)

0.317

−0.2 (−1.2, 1)

0.2 (− 1.3, 6.1)

0.480

potassium [mmol/L]

4.45 (4.1, 5.2)

4.4 (3.8, 5.1)

0.158

4.3 (3.9, 5.4)

4.3 (3.9, 5.1)

0.491

−0.2 (−0.9, 1)

− 0.1 (− 0.5, 0.5)

0.392

sodium [mmol/L]

140 (138, 142)

140 (137, 144)

0.111

140 (137, 145)

139 (137, 142)

0.069

−1 (−3, 4)

0 (−4, 3)

0.814

chloride [mmol/L]

104 (101, 106)

103 (100, 106)

0.275

104 (98, 109)

104 (98, 108)

0.733

0 (−4, 5)

1 (−5, 4)

0.952

carbon dioxide, C02 [mmol/L]

21 (17, 24)

21 (17, 25)

0.496

23 (18, 26)

22 (18, 25)

0.077

2 (−3,7)

0 (−6, 6)

0.158