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Table 3 Longitudinal analysis of sensitization to allergen extracts at 1, 3 and 6 years of age

From: Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood – a longitudinal analysis of long-term follow-up of a randomized controlled trial

Outcome

Year

ω-3 LCPUFAa

n (%)

Controla

n (%)

RR (95% CI)

P-value

Interaction

p-value

Adjusted RRb

(95% CI)

Adjusted

p-value

Interaction p-valueb

Any Sensitization

1

50/349 (14.33%)

63/317 (19.87%)

0.72 (0.51, 1.01)

0.06

0.16

0.73 (0.52, 1.02)

0.07

0.10

3

77/303 (25.41%)

74/279 (26.52%)

0.96 (0.73, 1.26)

0.76

 

0.97 (0.74, 1.27)

0.83

 

6

124/248 (50.00%)

116/232 (50.00%)

1.00 (0.84, 1.20)

> 0.99

 

1.05 (0.88, 1.25)

0.56

 

All years

  

0.94 (0.79, 1.12)

0.47

 

0.97 (0.82, 1.15)

0.76

 

Egg sensitization‡

1

34/349 (9.74%)

51/317 (16.09%)

0.61 (0.40, 0.91)

0.02

0.55

0.62 (0.42, 0.93)

0.02

0.54

3

11/307 (3.58%)

15/280 (5.36%)

0.67 (0.31, 1.43)

0.30

 

0.68 (0.32, 1.44)

0.31

 

6

6/248 (2.42%)

5/232 (2.16%)

1.12 (0.35, 3.63)

0.85

 

1.16 (0.36, 3.73)

0.81

 

All years

  

0.65 (0.42, 1.01)

0.05

 

0.67 (0.43, 1.02)

0.06

 

Peanut sensitization

1

15/349 (4.30%)

22/317 (6.94%)

0.62 (0.33, 1.17)

0.14

0.98

0.65 (0.34, 1.22)

0.18

0.98

3

12/307 (3.91%)

18/280 (6.43%)

0.61 (0.30, 1.24)

0.17

 

0.63 (0.31, 1.27)

0.20

 

6

18/250 (7.20%)

29/232 (12.50%)

0.58 (0.33, 1.01)

0.05

 

0.61 (0.35, 1.06)

0.08

 

All years

  

0.60 (0.37, 0.98)

0.04

 

0.63 (0.39, 1.02)

0.06

 

Cat sensitization

1

7/349 (2.01%)

5/317 (1.58%)

1.27 (0.41, 3.97)

0.68

0.11

1.30 (0.42, 4.00)

0.65

0.12

3

24/303 (7.92%)

11/277 (3.97%)

1.99 (1.00, 4.00)

0.05

 

2.02 (1.02, 4.02)

0.04

 

6

30/247 (12.15%)

27/231 (11.69%)

1.04 (0.64, 1.69)

0.88

 

1.07 (0.66, 1.74)

0.79

 

All years

  

1.30 (0.80, 2.13)

0.29

 

1.34 (0.83, 2.18)

0.23

 

Cashew sensitization

3

5/307 (1.63%)

11/280 (3.93%)

0.41 (0.15, 1.18)

0.10

0.56

0.43 (0.15, 1.20)

0.11

0.50

6

9/249 (3.61%)

16/231 (6.93%)

0.52 (0.24, 1.16)

0.11

 

0.55 (0.25, 1.25)

0.15

 

All years

  

0.48 (0.21, 1.08)

0.08

 

0.50 (0.22, 1.14)

0.10

 

D. Farinae sensitization

3

16/303 (5.28%)

15/277 (5.42%)

0.98 (0.49, 1.94)

0.94

0.15

0.98 (0.50, 1.94)

0.96

0.18

6

31/246 (12.60%)

49/231 (21.21%)

0.59 (0.39, 0.90)

0.01

 

0.62 (0.41, 0.93)

0.02

 

All years

  

0.68 (0.46, 1.00)

0.05

 

0.70 (0.47, 1.03)

0.07

 
  1. For ω-3 LCPUFA and control groups, data are number of subjects (percentage)
  2. Longitudinal analysis not performed for sensitization to ryegrass, olive, D. pteronyssinus and alternaria tenuis due to insufficient cases at 1/3 years
  3. Abbreviations: CI confidence interval, ω-3 LCPUFA long chain polyunsaturated fatty acid, RR relative risk
  4. a bAdjusted for enrolling centre, parity, child sex and maternal history of allergic disease
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World Allergy Organization Journal

ISSN: 1939-4551

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