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Table 3 Longitudinal analysis of sensitization to allergen extracts at 1, 3 and 6 years of age

From: Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood – a longitudinal analysis of long-term follow-up of a randomized controlled trial

Outcome Year ω-3 LCPUFAa
n (%)
Controla
n (%)
RR (95% CI) P-value Interaction
p-value
Adjusted RRb
(95% CI)
Adjusted
p-value
Interaction p-valueb
Any Sensitization 1 50/349 (14.33%) 63/317 (19.87%) 0.72 (0.51, 1.01) 0.06 0.16 0.73 (0.52, 1.02) 0.07 0.10
3 77/303 (25.41%) 74/279 (26.52%) 0.96 (0.73, 1.26) 0.76   0.97 (0.74, 1.27) 0.83  
6 124/248 (50.00%) 116/232 (50.00%) 1.00 (0.84, 1.20) > 0.99   1.05 (0.88, 1.25) 0.56  
All years    0.94 (0.79, 1.12) 0.47   0.97 (0.82, 1.15) 0.76  
Egg sensitization‡ 1 34/349 (9.74%) 51/317 (16.09%) 0.61 (0.40, 0.91) 0.02 0.55 0.62 (0.42, 0.93) 0.02 0.54
3 11/307 (3.58%) 15/280 (5.36%) 0.67 (0.31, 1.43) 0.30   0.68 (0.32, 1.44) 0.31  
6 6/248 (2.42%) 5/232 (2.16%) 1.12 (0.35, 3.63) 0.85   1.16 (0.36, 3.73) 0.81  
All years    0.65 (0.42, 1.01) 0.05   0.67 (0.43, 1.02) 0.06  
Peanut sensitization 1 15/349 (4.30%) 22/317 (6.94%) 0.62 (0.33, 1.17) 0.14 0.98 0.65 (0.34, 1.22) 0.18 0.98
3 12/307 (3.91%) 18/280 (6.43%) 0.61 (0.30, 1.24) 0.17   0.63 (0.31, 1.27) 0.20  
6 18/250 (7.20%) 29/232 (12.50%) 0.58 (0.33, 1.01) 0.05   0.61 (0.35, 1.06) 0.08  
All years    0.60 (0.37, 0.98) 0.04   0.63 (0.39, 1.02) 0.06  
Cat sensitization 1 7/349 (2.01%) 5/317 (1.58%) 1.27 (0.41, 3.97) 0.68 0.11 1.30 (0.42, 4.00) 0.65 0.12
3 24/303 (7.92%) 11/277 (3.97%) 1.99 (1.00, 4.00) 0.05   2.02 (1.02, 4.02) 0.04  
6 30/247 (12.15%) 27/231 (11.69%) 1.04 (0.64, 1.69) 0.88   1.07 (0.66, 1.74) 0.79  
All years    1.30 (0.80, 2.13) 0.29   1.34 (0.83, 2.18) 0.23  
Cashew sensitization 3 5/307 (1.63%) 11/280 (3.93%) 0.41 (0.15, 1.18) 0.10 0.56 0.43 (0.15, 1.20) 0.11 0.50
6 9/249 (3.61%) 16/231 (6.93%) 0.52 (0.24, 1.16) 0.11   0.55 (0.25, 1.25) 0.15  
All years    0.48 (0.21, 1.08) 0.08   0.50 (0.22, 1.14) 0.10  
D. Farinae sensitization 3 16/303 (5.28%) 15/277 (5.42%) 0.98 (0.49, 1.94) 0.94 0.15 0.98 (0.50, 1.94) 0.96 0.18
6 31/246 (12.60%) 49/231 (21.21%) 0.59 (0.39, 0.90) 0.01   0.62 (0.41, 0.93) 0.02  
All years    0.68 (0.46, 1.00) 0.05   0.70 (0.47, 1.03) 0.07  
  1. For ω-3 LCPUFA and control groups, data are number of subjects (percentage)
  2. Longitudinal analysis not performed for sensitization to ryegrass, olive, D. pteronyssinus and alternaria tenuis due to insufficient cases at 1/3 years
  3. Abbreviations: CI confidence interval, ω-3 LCPUFA long chain polyunsaturated fatty acid, RR relative risk
  4. a bAdjusted for enrolling centre, parity, child sex and maternal history of allergic disease