Table 3 Key dust mite allergen groups with known biochemical identity conferring allergenicity
From: International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem
Allergens Groups | Biochemical Identity | Mechanism of TH2immune induction |
|---|---|---|
Group 1 | Cystein protease | Increased permeability through disruption of airway and cutaneous epithelial tight junctions |
Group 2 Der p 2, Der f 2 | MD-2 like lipid-binding protein | Molecular mimicry of MD2 and DC activation via TLR4 TLR2 activation on DC |
Group 3 Der p 3, Der f 3 | Trypsin-like serine protease | Increased permeability through disruption of airway and cutaneous epithelial tight junctions PAR-2 activation in airway epithelial cells and keratinocytes |
Group 5 Blo t 5, Der p 5, Der f 5 | Lipid binding protein | TLR activation? |
Group 6 Der p 6, Der f 6 | Chymotrypsin-like serine protease | Increased permeability through disruption of airway and cutaneous epithelial tight junctions PAR-2 activation in keratinocytes |
Group 7 Der p 7, Der f 7 | Lipid binding Protein | Molecular mimicry of lipid binding protein and dendritic cell activation via TLR2, 3, 4 |
Group 9 Der p 9, Der f 9 | Collagenolytic protease | Increased permeability through disruption of airway and cutaneous epithelial tight junctions PAR-2 activation in airway epithelial calls and keratinocytes. |