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Table 3 Key dust mite allergen groups with known biochemical identity conferring allergenicity

From: International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

Allergens Groups Biochemical Identity Mechanism of TH2immune induction
Group 1 Cystein protease Increased permeability through disruption of airway and cutaneous epithelial tight junctions
Group 2
Der p 2, Der f 2
MD-2 like lipid-binding protein Molecular mimicry of MD2 and DC activation via TLR4
TLR2 activation on DC
Group 3
Der p 3, Der f 3
Trypsin-like serine protease Increased permeability through disruption of airway and cutaneous epithelial tight junctions
PAR-2 activation in airway epithelial cells and keratinocytes
Group 5
Blo t 5, Der p 5, Der f 5
Lipid binding protein TLR activation?
Group 6
Der p 6, Der f 6
Chymotrypsin-like serine protease Increased permeability through disruption of airway and cutaneous epithelial tight junctions
PAR-2 activation in keratinocytes
Group 7
Der p 7, Der f 7
Lipid binding Protein Molecular mimicry of lipid binding protein and dendritic cell activation via TLR2, 3, 4
Group 9
Der p 9, Der f 9
Collagenolytic protease Increased permeability through disruption of airway and cutaneous epithelial tight junctions PAR-2 activation in airway epithelial calls and keratinocytes.