Effects of poor hygiene on cytokine phenotypes in children in the tropics

Table 1 Proportions of children producing cytokines in spontaneous and SEB-stimulated peripheral blood leukocyte cultures by immunological phenotype

Cytokines	Overall % (N = 310)
		Spontaneous immune phenotype
		Low Response % (N = 251)	High Response % (N = 59)
Adaptive
IL-17	7.7	7.2	9.8
IFN-γ	30.6	26.7	46.0
IL-10	17.1	12.8	34.1
IL-13	60.0	53.3	86.4
IL-5	54.8	51.7	67.2
Innate
IL-6	15.5	0	76.2
IL-10	12.6	3.4	48.4
IL-8	41.6	27.3	97.6
TNF-α	32.6	19.8	82.7
		SEB-stimulation immune phenotype
		Low response %	Modified Th2 response %
Adaptive
IL-17	49.8	42.8	57.0
IFN-γ	52.6	46.7	58.6
IL-10	53.2	28.2	78.6
IL-13	52.6	14.4	91.3
IL-5	50.3	17.3	83.8

Shown are conditional probabilities estimated by latent class analysis for each of the two phenotypes. Entropy for spontaneous and SEB-stimulated was 0.895 and 0.701, respectively. Proportions of children producing low vs. high response phenotypes for spontaneous were 79.7 vs. 20.3 %, and for low vs. modified Th2 response for SEB-stimulation were 50.4 vs. 49.6 %

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