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Table 3 Exemplary cases of systemic reactions during skin prick test (SPT) with latex

From: Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement

Number of cases reported Type of ST Culprit agent (type of latex) Symptoms/fatalities Reference Comments (e.g. setting, age etc.)
1 SPT Liquid latex material Immediate flushing, tachycardia, urticaria, light-headedness Spaner et al. 1989 [260] 34 year old female Operating room nurse
1 SPT 10 % aqueous dispersion Cold, sweaty extremities, initial tachycardia, subsequent bradycardia, hypotension Bonnekoh and Merk 1992 [261] 17 year old female dentist’s assistance
1 SPT 100 HEP Hevea brasiliensis Dizziness, difficulty with breathing, wheezing, tachypnoea Nicolaou and Johnston 2002 [262] 39 year old female house wife
6 SPT extemporaneous extracts (dilutions of 1:1000, 1:100, and 1:10) (n = 5), commercial SPT solution (n = 1) Signs of anaphylaxis in different degrees Nettis et al. 2001 [48] 6 female patients with age ranging from 26-51
9 SPT 1:100,000 dilution of latex glove extract Systemic reactions Kelly et al. 1993 [44] 9 of 107 patients: 85 children with spina bifida, 15 health care workers, 7 others
2 or 3a SPT 50 % glycerine, 0.23 mg/mL total protein from gloves Pruritus, flushing, urticaria, angioedema, asthma, cough chest tightness, wheezing, dyspnea, eye itching, nasal congestion Valyasevi et al. 1999 [15] 2 or 3a patients from a clinic out of 1316
  1. ain one patient reason of anaphylactic reaction was not clear because he was also positive to aeroallergens