Management of patients with suspected hypersensitivity to a vaccine and patients with known allergy to a vaccine component (modified from Caubet et al. 2014; Printed with permission of Wiley) . *For egg allergic patients, see text (Approach to the patient with possible allergies to foods or other materials that may also be components of vaccines or vaccine packaging). **For patients with a positive skin test to a vaccine, consider risk benefit analysis based on serologic evidence of current immunity and level of risk for target disease. See Wood et al.