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Table 1 Characteristics of the 15 trials included in the meta-analysis and addressing the guideline’s Question 1: “Should probiotics vs. no probiotics be used in pregnant women?”.

From: A clinical reading on “World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics”

References

Population at risk of atopy

N° patients

Probiotic

Duration of ante-partum therapy

Duration of therapy in breastfed infants

Duration of therapy in infants fed with formulas

Kalliomaki et al. 2001 [4]

yes

159

Lactobacillus rhamnosus GG (ATCC 55103)

2-4 weeks

6 months

6 months

Rautava et al. 2002 [5]a

yes

62

Lactobacillus rhamnosus GG (ATCC 53103)

4 weeks

3 months

3 months

Abrahamsson et al. 2007 [6]

yes

232

Lactobacillus reuteri (ATCC55730)

4 weeks

12 months

12 months

Kukkonen et al. 2007 [7]

yes

1223

Lactobacillus rhamnosus GG (ATCC 55103),

Lactobacillus rhamnosus LC705 (DSM7061),

Bifidobacterium breve Bb99 (DSM13692),

Propionibacterium freudenreichiii ssp shermanii JS (DSM7076)

2-4 weeks

6 months

6 months

Huurre et al. 2008 [8]

yes

171

Lactobacillus rhamnosus GG (ATCC 55103)

Bifidobacterium lactis Bb12

6 months

end of breastfeeding

-

Marschan et al. 2008 [9]b

yes

98

Lactobacillus rhamnosus GG (ATCC 55103),

Lactobacillus rhamnosus LC705 (DSM7061),

Bifidobacterium breve Bb99 (DSM13692),

Propionibacterium freudenreichiii ssp shermanii JS (DSM7076)

2-4 weeks

6 months

6 months

Wickens et al. 2008 [10]

yes

512

Lactobacillus rhamnosus HN001,

Bifidobacterium animalis subspec lactis HN019

5 weeks

6 months

24 months

Kopp et al. 2008 [11]

yes

105

Lactobacillus rhamnosus GG ( ATCC 53103)

4-6 weeks

6 months

6 months

Niers et al. 2009 [12]

yes

156

Bifidobacterium bifidum W23,

Bifidobacterium lactis W52

Lactococcus lactis W58

6 weeks

 

12 months

Dotterud et al. 2010 [13]

no

415

Lactobacillus rhamnosus GG,

Bifidobacterium animalis subsp.Bb-12,

Lactobacillus acidophilus La-5

4 weeks

3 months

 

Kim et al. 2010 [14]

yes

112

Bifidobacterium bifidum BGN4,

Bifidobacterium lactis AD011,

Lactobacillus acidophilus AD031

8 weeks

3 months

4-6 months

Boyle et al. 2011 [15]

yes

250

Lactobacillus rhamnosus GG ( ATCC 53103)

4 weeks

  

Ou et al. 2012 [16]

Yes (maternal hystory)

191

Lactobacillus rhamnosus GG ( ATCC 53103)

4 months

6 months

6 months

Allen et al. 2012 [17]

the most of partecipants

454

Lactobacillus salivarius CUL61,

Lactobacillus paracasei CUL08,

Bifidobacteriums animalis ssp. lactis CUL34,

Bifidobacterium bifidum CUL20

4 weeks

6 months

6 months

Rautava et al. 2012 [18]

yes

241

Lactobacillus rhamnosus LP + Bifidobacterium longum (ATCC BAA-999)

or

Lactobacillum paracasei ST11 + Bifidobacterium longum (ATCC BAA-999 )

2 months

2 months

 
  1. aAnalysis of a subgroup of patients previous analyzed by Kalliomaki et al. [4]
  2. bAnalysis of a subgroup of patients previous analyzed by Kukkonen et al. [7]
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World Allergy Organization Journal

ISSN: 1939-4551

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