Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Metcalfe, Dean D.; Pawankar, Ruby; Ackerman, Steven J.; Akin, Cem; Clayton, Frederic; Falcone, Franco H.; Gleich, Gerald J.; Irani, Anne-Marie; Johansson, Mats W.; Klion, Amy D.; Leiferman, Kristin M.; Levi-Schaffer, Francesca; Nilsson, Gunnar; Okayama, Yoshimichi; Prussin, Calman; Schroeder, John T.; Schwartz, Lawrence B.; Simon, Hans-Uwe; Walls, Andrew F.; Triggiani, Massimo

doi:10.1186/s40413-016-0094-3

World Allergy Organization Journal

Table 1 Eosinophil surface proteins associated with allergic disease or aspects of allergic disease

From: Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Protein	Observation	Reference
CD9	Up-regulated during allergy season	[1]
CD40	Correlates inversely with esophagus eosinophilia in EoE	[6]
CD44	Higher in well-controlled than in poorly controlled asthma	[1]
CD44	Down-regulated in EoE	[5]
CD45RO	Up-regulated in mild-moderate asthma	[1]
CD48	Up-regulated in allergic asthma	[1]
CD66b (CEACAM8)	Up-regulated in untreated EoE	[133]
CD69	Up-regulated in severe atopic dermatitis	[10]
CD137 (TNFRSF9, ILA, 4-1BB)	Up-regulated in atopic dermatitis and allergic asthma	[134]
α_L integrin (CD11a)	Up-regulated in allergic asthma	[1]
α_M integrin (CD11b)	Up-regulated during allergy season	[1]
α_M integrin (CD11b)	Correlates inversely with PC₂₀	[1]
α_X integrin (CD11c)	Up-regulated in EoE	[5]
β₂ integrin (CD18)	Correlates with esophagus eosinophilia in EoE	[6]
CCR3	Down-regulated in EoE	[5]
CCR3	Correlates inversely with esophagus eosinophilia in EoE	[6]
CRTH2 (Prostaglandin D2 R2, CD294)	Up-regulated in EoE	[5]
FcαRI (CD89)	Up-regulated in allergic rhinitis or allergic asthma	[1]
FcεRII (CD23)	Up-regulated in EoE	[5]
FcγRIII (CD16)	Up-regulated in allergic rhinitis or allergic asthma	[1]
Galectin-3	Up-regulated in allergy	[1]
ICAM-1 (CD54)	Up-regulated in EoE	[5]
IL-2Rα (CD25)	Up-regulated in some patients with asthma	[7]
IL-17RA (subunit of IL- 25R)	Up-regulated in mild allergic asthma	[1]
IL-17RB (subunit of IL- 25R)	Up-regulated in mild allergic asthma	[1]
Neuropeptide S receptor	Up-regulated in severe asthma	[1]
Activated β₁ integrin (CD29)	Intermediate-activity state (recognized by mAb N29) increased in non-severe but not severe asthma	[1]
	Correlates inversely with FEV₁ after or during ICS withdrawal in mild asthma and predicts decreased FEV₁ in ROC curve analysis
	Correlates with FENO after ICS withdrawal in mild asthma
	Correlates inversely with FEV₁/FVC in younger subjects with non-severe asthma
	Correlates inversely with FEV₁/FVC in phenotype cluster 1 (mild atopic asthma).
	At 48 h after segmental lung antigen challenge, correlates with late-phase FEV₁ fall after whole-lung antigen challenge in mild allergic asthma
Activated β₂ integrin (CD18)	Intermediate-activity state (recognized by mAb KIM-127) correlates with BAL eosinophilia in mild allergic asthma	[1]
Activated FcγRII (CD32)	Activated state (recognized by mAb A17 or A27) increased in mild asthma	[1]
Activated FcγRII (CD32)	Correlates with FENO in asthma	[1]

Note: Observations refer to expression level, usually determined by flow cytometry, and are on blood eosinophils. For more original references, please see reference list in [1]

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ISSN: 1939-4551

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