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Table 1 Eosinophil surface proteins associated with allergic disease or aspects of allergic disease

From: Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Protein Observation Reference
CD9 Up-regulated during allergy season [1]
CD40 Correlates inversely with esophagus eosinophilia in EoE [6]
CD44 Higher in well-controlled than in poorly controlled asthma [1]
Down-regulated in EoE [5]
CD45RO Up-regulated in mild-moderate asthma [1]
CD48 Up-regulated in allergic asthma [1]
CD66b (CEACAM8) Up-regulated in untreated EoE [133]
CD69 Up-regulated in severe atopic dermatitis [10]
CD137 (TNFRSF9, ILA, 4-1BB) Up-regulated in atopic dermatitis and allergic asthma [134]
αL integrin (CD11a) Up-regulated in allergic asthma [1]
αM integrin (CD11b) Up-regulated during allergy season [1]
Correlates inversely with PC20
αX integrin (CD11c) Up-regulated in EoE [5]
β2 integrin (CD18) Correlates with esophagus eosinophilia in EoE [6]
CCR3 Down-regulated in EoE [5]
Correlates inversely with esophagus eosinophilia in EoE [6]
CRTH2 (Prostaglandin D2 R2, CD294) Up-regulated in EoE [5]
FcαRI (CD89) Up-regulated in allergic rhinitis or allergic asthma [1]
FcεRII (CD23) Up-regulated in EoE [5]
FcγRIII (CD16) Up-regulated in allergic rhinitis or allergic asthma [1]
Galectin-3 Up-regulated in allergy [1]
ICAM-1 (CD54) Up-regulated in EoE [5]
IL-2Rα (CD25) Up-regulated in some patients with asthma [7]
IL-17RA (subunit of IL- 25R) Up-regulated in mild allergic asthma [1]
IL-17RB (subunit of IL- 25R) Up-regulated in mild allergic asthma [1]
Neuropeptide S receptor Up-regulated in severe asthma [1]
Activated β1 integrin (CD29) Intermediate-activity state (recognized by mAb N29) increased in non-severe but not severe asthma [1]
Correlates inversely with FEV1 after or during ICS withdrawal in mild asthma and predicts decreased FEV1 in ROC curve analysis
Correlates with FENO after ICS withdrawal in mild asthma
Correlates inversely with FEV1/FVC in younger subjects with non-severe asthma
Correlates inversely with FEV1/FVC in phenotype cluster 1 (mild atopic asthma).
At 48 h after segmental lung antigen challenge, correlates with late-phase FEV1 fall after whole-lung antigen challenge in mild allergic asthma
Activated β2 integrin (CD18) Intermediate-activity state (recognized by mAb KIM-127) correlates with BAL eosinophilia in mild allergic asthma [1]
Activated FcγRII (CD32) Activated state (recognized by mAb A17 or A27) increased in mild asthma [1]
Correlates with FENO in asthma
  1. Note: Observations refer to expression level, usually determined by flow cytometry, and are on blood eosinophils. For more original references, please see reference list in [1]