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Table 3 Predictability of Baked Milk Tolerance by Testing

From: Debates in allergy medicine: baked milk and egg ingestion accelerates resolution of milk and egg allergy

 

SPT wheal

Specific IgE (kUA/L)

Suggested cut-off for OFCs

Nowak-Wegrzyn et al. [20]

CM < 5 mm = 100 % NPV [poor specificity]

CM IgE ≥35 = >50 % PPV

CM IgE 5.0 kU/L

CM 15 mm = 50 % PPV

Caubet et al. [21]

N/A

CM IgE 24.5 = 69 % PPV [poor sensitivity]

Casein IgE 5 kUA/L

Casein IgE 20.2 = 69 % PPV [poor sensitivity]

CM IgE 10 kUA/L

Casein IgE 4.95 = 89 % NPV

Bartnikas et al. [22]

CM <7 mm = 100 % NPV

CM IgE >20.6 = 100 % PPV

N/A

Casein >15 mm = 100 % PPV

Casein IgE >10.3 = 100 % PPV

Casein IgE 0.9 = 90 % NPV [poor sensitivity and specificity]

  1. SPT skin prick test, CM cow’s milk, PPV positive predictive value, NPV negative predictive value, OFC oral food challenge