Table 3 Associations between standardised vitamin D (25 (OH) D) levels and allergic disease outcomes
Allergic disease outcome | Incidencea | Unadjusted RRb (95 % CI) | Adjusted RRc (95 % CI) | Adjustedc |
|---|---|---|---|---|
P Value | ||||
Eczema at 1 year of age | 70/265 (26.4) | 0.89 (0.81, 0.97) | 0.88 (0.81, 0.96) | 0.002 |
Eczema with sensitisation at 1 year of age | 19/265 (7.2) | 0.85 (0.70, 1.04) | 0.84 (0.69, 1.01) | 0.07 |
Eczema at 3 years of age | 77/247 (31.2) | 0.94 (0.87, 1.01) | 0.93 (0.86, 1.01) | 0.07 |
Eczema with sensitisation at 3 years of age | 26/244 (10.7) | 0.87 (0.74, 1.02) | 0.85 (0.73, 1.00) | 0.051 |
Cumulative incidence of eczema by 3 years of age | 101/250 (40.4) | 0.92 (0.86, 0.98) | 0.92 (0.86, 0.97) | 0.005 |
Cumulative incidence of eczema with sensitisation by 3 years of age | 30/243 (12.3) | 0.85 (0.73, 0.98) | 0.83 (0.72, 0.96) | 0.01 |
IgE-mediated food allergy at 1 year of age | 4/260 (1.5) | 0.60 (0.41, 0.90) | - | 0.01d |
IgE-mediated food allergy at 3 years of age | 7/229 (3.1) | 0.78 (0.54, 1.13) | 0.77 (0.50, 1.17) | 0.22 |
Cumulative incidence IgE-mediated food allergy by 3 years of age | 8/228 (3.5) | 0.80 (0.57, 1.12) | 0.78 (0.55, 1.11) | 0.17 |
Any sensitisation at 1 year of age | 36/260 (13.8) | 0.95 (0.84, 1.09) | 0.94 (0.83, 1.07) | 0.36 |
Any sensitisation at 3 years of age | 52/229 (22.7) | 0.96 (0.87, 1.07) | 0.95 (0.86, 1.05) | 0.28 |
Cumulative incidence any sensitisation by 3 years of age | 66/230 (28.7) | 0.96 (0.88, 1.05) | 0.95 (0.87, 1.03) | 0.23 |
Cumulative incidence of allergic rhinitis by 3 years of age | 39/246 (15.9) | 0.97 (0.86, 1.10) | 0.98 (0.87, 1.11) | 0.80 |
Cumulative incidence of allergic rhinitis with sensitisation by 3 years of age | 13/245 (5.3) | 0.95 (0.75, 1.19) | 0.94 (0.75, 1.18) | 0.60 |
Cumulative incidence of asthma by 3 years of age | 32/248 (12.9) | 1.03 (0.91, 1.17) | 1.03 (0.90, 1.18) | 0.67 |
Cumulative incidence of asthma with sensitisation by 3 years of age | 5/245 (2.0) | 1.05 (0.74, 1.48) | - | 0.80d |
Cumulative incidence of any allergic disease by 3 years of age | 137/240 (57.1) | 0.95 (0.90, 0.99) | 0.95 (0.90, 0.99) | 0.02 |
Cumulative incidence of any allergic disease with sensitisation by 3 years of age | 40/228 (17.5) | 0.88 (0.78, 1.00) | 0.87 (0.77, 0.98) | 0.03 |
Respiratory tract infections by 1 year of age | 45/267 (16.9) | 1.08 (0.98, 1.20) | 1.07 (0.97, 1.18) | 0.18 |
Cumulative incidence of respiratory tract infections by 3 years of age | 70/250 (28.0) | 1.03 (0.95, 1.11) | 1.02 (0.95, 1.10) | 0.61 |