Table 2 Production of Th2 (IL-5 and IL-13), Th1 (IFN-γ), T reg (IL-10) and Th17 (IL-17) cytokines by peripheral blood leukocytes exposed to different culture conditions stratified by rural vs. urban residence
Cytokine Production | Spontaneous | SEB* | Ascaris | HDM |
|---|---|---|---|---|
Md(Q1-Q3) | Md(Q1-Q3) | Md(Q1-Q3) | Md(Q1-Q3) | |
Rural Area | ||||
IL-5 | 70 (41–154) | 2940 (2126–4452) | 76 (21–228.5) | 17 (9–37) |
IL-13 | 269 (202–475) | 4511 (3585–6125) | 49 (18–128) | 30 (14–61) |
IFN-γ | 86 (34–250) | 638 (285–2450) | 61 (18–132) | 49 (15–131) |
IL-10 | 14 (8–39) | 377 (239–588) | 12 (7–28) | 25 (7–62) |
IL-17 | 16 (9–40) | 327 (256–419) | 13 (7–17) | 15 (6–21) |
Urban Area | ||||
IL-5 | 67 (41–152) | 2692 (1900–3992) | 53 (19–141) | 19 (8–56) |
IL-13 | 321 (213–564) | 4148 (3146–5531) | 44 (16–121) | 35 (14–62) |
IFN-γ | 169 (68–373) | 391 (214–873) | 63 (22–128) | 46 (10–177) |
IL-10 | 16 (8–52) | 392 (268–591) | 15 (6–35) | 25 (10–60) |
IL-17 | 11 (7–55) | 335 (231–490) | 8 (4–23) | 14 (4–23) |