Figure 5

Effect of Vitamin D supplementation in different therapy protocols for CU: a. Effect of Vitamin D (VD), antihistamines(H) and corticosteroids (S) on VAS of CU patients. Patients were treated with VD alone, H + S and VD + H + S for 6 weeks. VAS was calculated at the start of the study (baseline) and after 6 weeks of treatment. Values are presented as mean ± SEM. *, P < 0.05; **, P < 0.01; ***,P < 0.0001. Number of patients in each group is represented in parentheses. b. Effect of Vitamin D (VD), antihistamines(H) and corticosteroids (S) on 5-D score of CU patients. Patients were treated with VD alone, H + S and VD + H + S for 6 weeks. 5-D score was calculated at the start of the study (baseline) and after 6 weeks of treatment. Number of patients in each group is represented in parentheses. Values are presented as mean ± SEM. *, P < 0.05; **, P < 0.01; ***,P < 0.0001. The primary end point (VAS and 5D-Score) was evaluated by using an analysis of covariance model with the factors of treatment and center and with the baseline score as the covariate. For the treatment contrast between the three groups a, b and c, a 95% CI and a 2-sided P value were calculated. Mean score (VAS, 5-D) changes within group VD and group H + S and group VD + H + S were compared, using paired t-test (keeping normality of the observation into considerations). Intergroup comparison at different time-points was done using analysis of variance test (ANOVA). A P < 0 · 05 was taken to be statistically significant.