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Figure 2 | World Allergy Organization Journal

Figure 2

From: Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens

Figure 2

Role of Treg and Breg cells in the suppression of allergic inflammation. The balance between Th2 cells and Treg cells is decisive for the development or suppression of allergic inflammation. Treg cells and their cytokines suppress Th2 type immune responses and contribute to the control of allergic diseases in several major ways. Red arrows indicate the regulatory and suppressive effects of Treg cells, which exert their regulatory functions directly or indirectly on B cells by inducing IgG4 and IgA and suppressing IgE; on vascular endothelium by suppressing Th2 cell homing to tissues; on mast cells, basophils and eosinophils via direct and indirect suppressive effects; and on directly and indirectly suppression of epithelial cell activation and proinflammatory properties. In addition, B reg cells also suppress effector T cells and contribute to IgG4 synthesis.

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