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Figure 3 | World Allergy Organization Journal

Figure 3

From: The care pathway for children with urticaria, angioedema, mastocytosis

Figure 3

The diagnostic pathway of Mastocytosis. Mastocytosis is essentially suspected on clinical ground. Because mastocytosis is due to a clonal proliferation of MCs, the diagnosis is established by detection of MCs with abnormal morphologic features and immunophenotypes in the bone marrow or other extracutaneous organs and investigating specific mutations in its growth factor (c-KIT) receptor [21]. The SCORMA Index provides a standardized information on the severity of CM, with no burden for patients, which is particularly important in children. The simultaneous assessment of SCORMA Index and tryptase level is essential in all cases of pediatric mastocytosis [23].

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