Figure 2From: The care pathway for children with urticaria, angioedema, mastocytosis The diagnostic pathway of Hereditary Angioedema (HAE). According to the 2010 International Consensus algorithm for diagnosis, therapy and management of HAE, the diagnosis should be confirmed by measuring serum complement factor 4 (C4) and serum C1-inhibitor protein and its functional levels [27].Back to article page