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Safety of meloxicam oral provocation challenge in patients with NSAID reaction

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Background

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used drug groups worldwide, for their significant properties analgesic and anti-inflammatory. Induce a variety of adverse reactions, both type A (related to the effects of the drug) and type B (related to individual response). Although the mechanisms underlying the adverse effects remain unclear, inhibition of cyclooxygenase (COX) seems to be the most accepted explanation. For their significant analgesic, antipyretic and anti-inflammatory, constitute an essential medicine for the treatment of several diseases, making it imperative to find a safe alternative in patients who report a hypersensitivity reaction to AINE.

Objective

To evaluate the safety of meloxicam as analgesic and anti-inflammatory alternative for patients who have experienced a hypersensitivity reaction to a NSAID.

Methods

We retrospectively evaluated patients who had reported an adverse reaction to several drugs of the NSAID group and had been subjected to a challenge with Meloxicam, between 2010-2013, in our allergy service in Medellin, Colombia.

Results

A total of fifty-seven patients reported hypersensitivity reactions to two or more NSAIDs, nineteen patients reported an anaphylactic reactions. All were challenged with meloxicam, thirty-six patients with incremental doses of 1.5, 3, 4.5 and 6 mg for a total dose of 15 mg, seventeen patients with a total dose of 7.5 mg, one patient to 10mg and one patient 5 mg for their age. Fifty-five patients had a negative test challenge, two patients (3.5%) with a positive challenge, both with skin symptoms (hives and angioedema).

Conclusion

Meloxicam is an anti-inflammatory analgesic and safe alternative for patients who have experienced a hypersensitivity reaction to 2 or more NSAIDs.

References

  1. 1.

    Maria Jose Torres, Esther Barrionuevo, Marek Kowalski, Miguel Blanca: Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs. Immunol Allergy Clin N Am. 2014, 34: 507-524. 10.1016/j.iac.2014.04.001.

  2. 2.

    Celik GE, Erkekol FÖ, Aydın Ö, Demirel YS, Mısırlıgil Z: Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?. Allergol Immunopathol (Madr). 2013, 41 (3): 181-188. 10.1016/j.aller.2012.03.006.

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Author information

Correspondence to Cristina Isabel Herrera Morales.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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