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Serum leptin and adiponectin levels correlate with mast cell activation during exercise-induced bronchospasm in asthmatic children

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The aim of this study was to address the correlation between leptin, adiponectin and exercise induced bronchospasm (EIB) by measuring urinary metabolites of mast cell mediators such as 9α,11β-PGF2, LTE4.


Seventy-two prepubertal children from the ages of 6 years to 10 years were recruited in the study. They comprised: asthmatic with EIB (n=24), asthmatic without EIB (n=21), and healthy controls (n=27). We measured exhaled nitric oxide (eNO) and serum eosinophilic cationic protein (ECP), leptin, adiponectin and cytokines. The urinary concentrations of LTE4 and 9α,11β-PGF2 were measured. The present study also performed pulmonary function tests: baseline, post-bronchodilator inhalation, methacholine inhalation and exercise. The area under the forced expiratory volume in one second (FEV1)-time curve quantified the severity of EIB over a 20-minute period after exercise (AUC20).


The post-exercise urinary excretion of 9α,11β-PGF2 in the asthmatics with EIB increased significantly compared with asthmatics without EIB. The post-exercise urinary excretion of LTE4 was not significantly difference between the two groups. The maximal decreases in % FEV1 after exercise were positively correlated with leptin levels and negatively with serum adiponectin levels in asthmatic children. Leptin presented positive associations correlated with post-exercise urinary excretion of 9α,11β-PGF2, LTE4 and adiponectin presented negative associations correlated with post-exercise urinary excretion of LTE4


Serum concentrations of the adipocyte-derived hormones leptin and adiponectin are correlated with EIB/BHR and urinary metabolites of mast cell mediators induced by exercise challenge in asthmatic children.

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Correspondence to Jae-Won Oh.

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