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Serum total IgE, ascaris lumbricoides specific IgE and eosinophils in parasites-infected children in a tropical area

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Background

This study investigated the relationship between total IgE and Ascaris lumbricoides specific IgE and eosinophils in children from endemic areas to assess the Th2-type immune response in a population that comprised 205 children with aged 1-10 years, and of low socioeconomic status.

Methods

Fecal samples were analysed by the methods of Blagg and Kato-katz. The serum levels of total IgE and A. lumbricoides specific IgE were determinated by ImmunoCAP (Pharmacia) and the eosinophils were counted in peripheral blood.

Results

The results showed a prevalence of 89% (182) for intestinal parasites. A. lumbricoides was detected in 140 (68%) children. The levels of total and specific IgE and eosinophils presented values above those of standard reference (median 480 KU/L and 0,74 KUA/L and 8%, respectively). Total IgE, A. lumbricoides specific IgE and eosinophils were significantly higher in the A. lumbricoides positive children as compared to A. lumbricoides negative ones (p = 0.02, <0.01 and 0.03).

Conclusions

Our results showed that parasites intestinal infection, particularly A. lumbricoides, induced a Th2-type immune response with production of the total and specific IgE and eosinophils.

Author information

Correspondence to Valéria Soraya De Farias Sales.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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