- Meeting abstract
- Open Access
Serum total IgE, ascaris lumbricoides specific IgE and eosinophils in parasites-infected children in a tropical area
World Allergy Organization Journal volume 8, pageA223 (2015)
This study investigated the relationship between total IgE and Ascaris lumbricoides specific IgE and eosinophils in children from endemic areas to assess the Th2-type immune response in a population that comprised 205 children with aged 1-10 years, and of low socioeconomic status.
Fecal samples were analysed by the methods of Blagg and Kato-katz. The serum levels of total IgE and A. lumbricoides specific IgE were determinated by ImmunoCAP (Pharmacia) and the eosinophils were counted in peripheral blood.
The results showed a prevalence of 89% (182) for intestinal parasites. A. lumbricoides was detected in 140 (68%) children. The levels of total and specific IgE and eosinophils presented values above those of standard reference (median 480 KU/L and 0,74 KUA/L and 8%, respectively). Total IgE, A. lumbricoides specific IgE and eosinophils were significantly higher in the A. lumbricoides positive children as compared to A. lumbricoides negative ones (p = 0.02, <0.01 and 0.03).
Our results showed that parasites intestinal infection, particularly A. lumbricoides, induced a Th2-type immune response with production of the total and specific IgE and eosinophils.