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Evaluation of cow's milk allergy


The prevalence of food allergy (FA) is increasing; consequently the number of patients on elimination diet (ED) due to a suspected diagnosis is also increasing. Diagnosis of food allergy should be based on a convincing history of allergic reactions or on the result of an oral food challenge test. The oral food challenge test (OFC) is the most reliable clinical procedure for diagnosing food allergy.


The goal of this study was evaluated the proportion of individuals that were following an elimination diet unnecessarily, because of either acquired tolerance or misdiagnosis. A retrospective analysis of patient’s records was made. We evaluated patients that were following elimination diet of cow´s milk. They underwent oral challenge with cow´s milk. The oral food challenge was carried out for two purposes: to confirm the diagnosis of cow's milk allergy or to demonstrate development of clinical tolerance to allergic food. The oral food challenge was performed like open test and double bind placebo controlled.


The oral challenge to cow´s milk were performed in 33 patients with a mean age of 17 years old (1-86 yo). In this series 63.6% patients were female. Atopic diseases were recorded in 45% of patients (15/33). Among the OFC, 20 were performed to confirm diagnosis of cow´s milk allergy; and 13 to demonstrate development of clinical tolerance in patients previously allergic. We found 27/33 (81%) negative OFC. The food challenge test confirmed food allergy to cow milk only in 4/20 patients (20%) who had suspected milk allergy and were following elimination diet. The positive results in specific IgE and in skin prick tests were recorded in 48.1% of patients. According to the open exposure tests and double-blind, placebo controlled food challenge tests these patients are only sensitized to cow's milk without clinical symptoms of allergy. Among the patients allergic to cow's milk 91% (11/12) were already tolerant to milk.


The mean age of patients was high. Most of them were following an elimination diet unnecessary, since they did not have cow´s milk allergy or they were tolerant. The lack of specialized services to perform oral challenge tests slows diagnostic confirmation.

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Correspondence to Patricia Salles Cunha.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Cunha, P.S., Simis, N.P., Saliba, B.G. et al. Evaluation of cow's milk allergy. World Allergy Organ J 8, A183 (2015).

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