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Wheezing in low birth weight infants


The majority of children with asthma develop symptoms such as wheezing in the first years of life. Low birth weight is considered as one of the risk factors for wheezing. The aim of this study was to describe the prevalence of wheezing during the first year of life in low birth weight infants, using the International Study of Wheezing in Infants (EISL).


Parents of infants aged between 12 and 15 months, residents in six Brazilian cities: Belém, Belo Horizonte, Cuiaba, Curitiba, Recife and São Paulo, participated in interviews between 2005 and 2010 answered the questionnaire EISL. The infants were divided according to birth weight: normal weight (NW= 2,500g or more) or low birthweight (LW = less than 2,500g). Infants were also divided according to the frequency of wheezing episodes: recurrent wheezing (RWh, three or more episodes) and severe recurrent wheezing (SRWh, six or more episodes or were hospitalized for wheezing).


12,582 valid questionnaires were considered, and 11,411 (90.7%) infants were born with NW and 1,171 (9.3%) with LW. For the RWh, was 2,488 (21.9%) infants in the NW group and 331 (28.3%) in LW group (p <0.001). Presented SRWh, 1,491 infants (13.1%) of the NW group and 248 (21.2%) of LW (p <0.001) group.


The prevalence of wheezing, especially in low birth weight infants is very high. Actions against smoking and complete pre-natal care would decrease the chances of the birth of low weight children.

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Correspondence to Gustavo Falbo Wandalsen.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Wandalsen, G.F., Neto, H.J.C., Aranda, C. et al. Wheezing in low birth weight infants. World Allergy Organ J 8, A163 (2015).

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