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  • Meeting abstract
  • Open Access

Severe combined immunodeficiency: case report of alogenic, haploidentical bone marrow transplantation

  • Fernanda Silveira1,
  • Liziane Nunes1,
  • Paula Lauria1,
  • Abelardo Neto1,
  • Sandra Bastos1,
  • Flavia Anisio1,
  • Patricia Lima1,
  • Franciane Silva1,
  • Juliana Fernandes2 and
  • Celso Ungier1
World Allergy Organization Journal20158:634

Published: 8 April 2015


Severe combined immunodeficiency (SCID) is characterized by important impairment in differentiation of T and/or B lymphocytes and occasionally Natural Killer cells, representing a pediatric emergency. A case of immunodeficiency is described emphasizing symptoms, diagnosis and answer after bone marrow transplantation.


Case report of a 2 years old male patient with severe combined immunodeficiency (SCID), diagnosed at 9 months after hospitalization due to failure to thrive, chronic diarrhea and pneumonia. Evolved with recurrent respiratory and gastrointestinal infections although using prophylaxis and immunoglobulin infusion. Alogenic, haploidentical transplantation was carried out with positive selection of CD34+, at 18 months of age due no compatible donor been found.


Satisfactory answer after transplantation keeping infusion of IV immunoglobulin with clinical and laboratorial favorable evolution.


Bone marrow transplantation when succeeds is supposed to restore lymphocyte system diminishing risks of severe and fatal infections.


Written informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.

Authors’ Affiliations

Instituto Nacional De Saude Da Mulher, Da Criança e Do Adolescente Fernandes Figueira - IFF/ Fiocruz, Brazil
Hospital Israelita Albert Einstein, Brazil


© Silveira et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.