A novel rapid (20-minute) IL-6 release assay using blood mononuclear cells of patients with various clinical forms of drug induced skin injuries

Table 3 Evaluation of the parallel in vitro - in vivo tests in the two groups

Parameters	" *Test A*" solution	%	" *Test B*" solution	%
Total N of parallel tests	99		85
Both negative	42		54
Both positive	41		12
Neg. IL-6, pos. in vivo*	7		15
Pos. IL-6, neg. in vivo**	9		5
Sensitivity		85.4		44.4
Specificity		82.4		93.1
Reliability		83.8		77.6
Positive predictive value		82.0		70.6
Negative predictive value		85.7		78.2

^*false negative.
^**false positive.
"Test A": 100 mM NaCl, 24 mM KCl, 10 mM CaCl₂, 10 mM MgCl₂, 11 mM glucose; pH:7.2.
"Test B": 145 mM NaCl, 21 mM KCl, 0.7 mM CaCl₂, 0.7 mM MgCl₂, 11 mM glucose; pH:7.2.
*in vivo: "Test A": oral provocation 2, intradermal 5 tests were positive.
*in vivo: "Test B": oral provocation 5, epicutaneous 2, intradermal 8 tests were positive.
**in vivo: "Test A": oral provocation 5, epicutaneous 1, intradermal 3 tests were negative.
**in vivo: "Test B": oral provocation 3, intradermal 2 tests were negative.

ISSN: 1939-4551