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Table 1 Distribution of clinical manifestations of drug hypersensitivity from " Test A " group (values are given in % of cases)

From: A novel rapid (20-minute) IL-6 release assay using blood mononuclear cells of patients with various clinical forms of drug induced skin injuries

 

IL-6 release pattern

Phenotypes

with peak at 0.15 μM, (n = 37 tests) I

with peak at 0.35 μM, (n = 67 tests) II

with peak at 0.5 μM, (n = 38 tests) III

with 2 or more positivities (n = 65 tests) IV

1

Generalized urticaria ± ANO2

17

18

11

18

2

Systemic Anaphylaxis ± ANO

23

24

24

28

3

DRESS3 (culprit/non-culprit*)

3

0

3*

0

4

Generalized MPE4 (>18%)

14

16

8

20

5

Localized MPE (<18%)

6

4

8

5

6

Disseminated fixed drug eruption

1

2

0

0

7

Erythema multiforme

0

2

0

2

8

Asthma, severe itch

1

0

0

0

9

Generalized disseminated dermatitis

9

2

11

8

10

Small patchy urticaria

3

9

8

5

11

Localized ANO

14

17

18

8

12

Leg dermatits ± purpurae

0

3

3

5

13

Circumscribed vesiculae

3

0

3

0

14

Erythema annulare centrifugum/E.nodosum

6

3

3

1

  1. 2ANO- angioneurotic edema.
  2. 3DRESS –drug rash with eosinophilia and systemic symptoms.
  3. 4MPE- maculopapular exanthema.
  4. *non-culprit drug representation of a single case.
  5. Boldface number in column II marks culprit.