Volume 7 Supplement 1

2013 WAO Symposium on Immunotherapy and Biologics

Open Access

Poster 1008: Dialyzable leukocyte extracts as adjuvant treatment for allergic rhinitis

  • Toni Angela Homberg1,
  • Rodolfo Ivan Lara2,
  • Sonia Mayra Pérez-Tapia1 and
  • María Del Carmen Jiménez Martínez3
World Allergy Organization Journal20147:23

https://doi.org/10.1186/1939-4551-7-S1-P5

Published: 3 February 2014

Background

Dialyzable leukocyte extracts (DLE) are human blood derived peptides less than 12kDa in size. DLE are hypothesized to induce a TH1 response, which makes them useful in the treatment of allergic disease. The purpose of this study was to determine the changes in symptomatology of patients with moderate and severe allergic rhinitis treated with standard treatment plus DLE.

Methods

We analyzed the clinical files of 68 patients receiving dialyzable leukocyte extracts as adjuvant treatment for moderate to severe allergic rhinitis in the period between 2009 and 2013, at our immunology department. All patients receiving DLE signed an informed consent as part of a running protocol (IC-12-001) authorized by the ethics committee and health department. Patients had different standard treatments for allergic rhinitis, such as antihistamines, nasal corticosteroids, leukotriene inhibitors and immunotherapy in varying combinations. Oral DLE was added to standard treatment in patients that remained symptomatic. The initial DLE dose varied between 1 and 2 Units (5mL/Unit) per week.

Results

28 (53.8%) female and 24 (46.2%) male patients ages 0-64 with a mean age of 17.3±17.5yrs with moderate to severe allergic rhinitis added DLE to their treatment. After 1 to 5 months, 52 (76.5%) reported improved symptoms, 11 (16.2%) abandoned treatment, 5 (7.4%) reported no improvement. No patients presented severe adverse effects. Of the 52 patients who reported improvement, 6 (11.5%) were asymptomatic, 32 (61.5%) mentioned general improvement of symptoms, 4 (7.7%) reported only decreased nasal congestion, 13 (25%) reported less frequent upper respiratory infections. 2 patients (3.8%) with concomitant asthma suspended the use of bronchodilators.

Conclusions

DLE may be beneficial as adjuvant treatment for allergic rhinitis. Although patient self-reported improvement is subjective, this study lays the ground for more objective measurements of drug response in the future. Interestingly, it helped decrease the use of bronchodilators in 2 cases with concomitant asthma.

Authors’ Affiliations

(1)
Instituto Politécnico Nacional
(2)
"Conde de Valenciana" Foundation
(3)
Faculty of Medicine, Universidad Nacional Autónoma de México

Copyright

© Homberg et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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