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  • Poster presentation
  • Open Access

Poster 2010: A study assessing the safety and efficacy of subcutaneous immunotherapy with a dust mite vaccine with the adjuvant l-tyrosine in a highly sensitized population in a Latin-American city

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World Allergy Organization Journal20147:40

  • Published:


  • Asthma
  • Data Base
  • Systemic Reaction
  • Rhinitis
  • Allergic Rhinitis


In Medellín-Colombia dust mite allergy is prevalent with high intensity of sensitization. We intended to describe the tolerability and efficacy of a new vaccine with a new adjuvant L-tyrosine in this population.


We realized a 2 years ambispective study for assessment safety and efficacy of subcutaneous immunotherapy with a dust mite vaccine with the adjuvant L-tyrosine. We reviewed the data of 292 patients with allergic rhinitis and/or asthma. They are sensitized to Dermatophagoides pteronyssinus or Dermatophagoides farinae and or Blomia tropicallis. A data base was constructed to allow complete assessment of the characteristics of the patients. We used the grading system proposed by the World Allergy Organization for the classification of the systemic reaction.



The subjects received a total of 3760 doses and 40 systemic adverse reactions were registered (reaction rate 1.06%). Of this 40 systemic reactions, 34 were in different patients and 6 patients had 2 reactions each. 28 reactions were grade 1, 2 and only one reaction was graded 3 and all were kept under monitoring until complete recovery from the event. 11 reactions were grade 1 and resolved with antihistamines alone (1z). No patients died and none patient was admitted or required ICU or intubation. Reactions were more common in patients with allergic rhinitis (57%) than in asthmatics (30.8%). 90 % of the reactions occurred with the allergen vaccine with mixture of D. pteronyssinus plus D. farinae 50%+50 % (16.666 TU/0.5 ml).


86.3 % of the patients improved markedly their clinical scores and or medication requirements, the response were partial for 7.1 % and absent for 6.7 %. The efficacy was assessment by medical criteria and was grater in those patients that don't had systemic adverse reactions in contrast to whom had systemic reactions (88.9 vs. 66.7%).


Subcutaneous Immunotherapy with L-tyrosine adjuvant for dust mite allergens is safe and effective in a highly sensitized population in a Latino-American Tropical City.

Authors’ Affiliations

Universidad de Antioquia, I.P.S Universitaria-Clinica León XIII, Medellin, Colombia
IATM, Medellin, Colombia
Universidad de Buenos Aires, Fundacion Cidea, Buenos Aires, Argentina


© Villa et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.