High-resource countries1 | Limited-resource countries2 | |
---|---|---|
Definition of anaphylaxis, eg. serious, life-threatening generalized allergic or hypersensitivity reaction | need ↑ awareness of a current anaphylaxis definition for clinical use | need ↑ awareness of a current anaphylaxis definition for clinical use |
Epidemiology | need integration of the clinical criteria for diagnosis of anaphylaxis with ICD-9 and ICD-10 codes; need more reliable prevalence estimates in healthcare settings and in the general population; and need more reliable prevalence estimates of mortality rates from different triggers in different patient populations | need concurrent epidemiologic studies of anaphylaxis using similar methods in different countries in order to obtain reliable prevalence estimates in the general population |
Patient risk factors and co-factors relevant to anaphylaxis | need ↑ awareness of patient risk factors for severe or fatal anaphylaxis, eg. asthma, CVD and MCAD; and need ↑ awareness of the role of co-factors such as exercise, ethanol, NSAIDs, emotional stress, acute infection, perimenstrual status | need baseline information about the prevalence of asthma, CVD, and MCAD so their relationship with anaphylaxis can be ascertained; need ↑ awareness of potential patient risk factors and co-factors; insights might be obtained from studies of fatal episodes3 |
Underlying mechanisms | need greater understanding of IgE-dependent, IgE-independent, and non-immunologic mechanisms (direct mast cell activation) | need greater understanding of IgE-dependent, IgE-independent, and non-immunologic mechanisms |
Triggers (causes, elicitors, or inducers) | need improved standardization of allergens, a standardized mechanism for reporting novel triggers, and continued efforts to standardize protocols for skin tests and challenge tests | need more comprehensive information about newly-discovered allergen triggers, allergens in some geographic areas, and certain groups of allergens, eg. reptile venoms and helminths |