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Table 3 Diagnosis of anaphylaxis: summary of collaborating organizations' principal anaphylaxis guidelines 1

From: International consensus on (ICON) anaphylaxis

  WAO Guidelines AAAAI/ACAAI Guidelines EAACI Guidelines
Symptoms and signs (typically within minutes to hours after exposure; multi-system; rapid progression) describe symptoms and signs in detail; Table 2 describe symptoms and signs; list frequency of symptoms and signs in different organ systems; Table E1 describe symptoms and signs; Figure 1
Clinical criteria for diagnosis of anaphylaxis primary emphasis on clinical diagnosis; clinical criteria for diagnosis are listed and illustrated; Table 1, Figure 3 primary emphasis on clinical diagnosis: state “the history is the most important tool”; clinical criteria for diagnosis are listed; Figure E1 primary emphasis on clinical diagnosis: clinical criteria for diagnosis are listed; Box 4
Laboratory tests for confirmation of the clinical diagnosis describe use of tryptase or histamine measurements and other tests in a supportive role; emphasize correct timing of blood samples; Table 3 describe use of tryptase or histamine measurements and other tests in a supportive role; emphasize correct timing of blood samples; Table E3 describe use of tryptase measurements in a supportive role
Differential diagnosis comprehensive list provided; additional laboratory tests for ruling out other diagnoses are described; Table 4 comprehensive list provided; additional laboratory tests for ruling out other diagnoses are described; Tables E2, E3 comprehensive list provided, including detailed list of neuropsychiatric diseases; Box 5
Diagnosis of anaphylaxis in special populations include reference ranges for vital signs in infants and children, and discuss relevant clinical and lab issues in infants, pregnant women and the elderly; Figure 1 include normal values for vital signs in infants and children; Table E4 describe patient-specific factors: examples include adolescence, advanced age, and gender; Box 6
  1. 1For details, see ICON: Anaphylaxis text page 5 and references 2, 3, and 4, including the tables, figures, and boxes from these references that are mentioned above in this Table.