Table 5 WAO Grading system for SLIT local adverse events
From: Sublingual immunotherapy: World Allergy Organization position paper 2013 update
Symptom/sign (see Table1) | Grade 1 – Mild | Grade 2 – Moderate | Grade 3 - Severe | Unknown severity |
|---|---|---|---|---|
Pruritus/swelling of mouth, tongue or lip | Not troublesome | Troublesome | • Grade 2 | The treatment is discontinued but there is no subjective and/or objective description of the severity from the patient/physician |
Throat irritation | AND | OR | AND | |
Nausea | No symptomatic treatment required | Requires symptomatic treatment | • SLIT discontinued because of local side effects | |
Abdominal pain | AND | AND | ||
Vomiting | No discontinuation of SLIT because of local side effects | No discontinuation of SLIT because of local side effects | ||
Diarrhea | ||||
Heartburn | ||||
Uvular oedema | ||||
Each local adverse event can be early (<30 minutes) or delayed | ||||