Table 2 Direct comparisons of SLIT and SCIT for efficacy

Eifan, 2010 [27]

5–12

16 SCIT

2

Mite

1 y

SCIT 111 mg Der p 1/156 mg Der f 1

RA

Significant reduction of total rhinitis and asthma score, medication score, VAS, and skin reactivity P < 0.05 versus pharmacotherapy for both SCIT and SLIT. No difference between routes of administration.

Randomized, open, controlled

16 SLIT

1

16 CON

2

SLIT 295.5 mg Der p 1/f 1

Keles, 2011 [24]

5–12

15 SCIT

2

Mite

18 mo

Der p 1: 53 mcg SLIT and 42 mcg SCIT

A

Decreased asthma attacks and use of steroids at 4, 12, 18 mo for SCIT and SCIT+SLIT, at 12 mo only for SLIT. No change in VAS for asthma with SCIT or SIT alone.

Double blind, double dummy, controlled

15 SLIT

2

15 SLIT

1

+ SCIT

15 CON

3

Yukselen, 2012 [62]

7–14

10 SCIT

1

Mite

1 y

173,733 TU (86,866.5 TU D pt. and 86,866.5 TU Df).

RA

Significant reduction in symptom and medication score versus baseline with both treatments. SCIT better than SLIT versus placebo.

10 SLIT

1

Double blind, double dummy, placebo controlled

10 PLA

0