From: Sublingual immunotherapy: World Allergy Organization position paper 2013 update
Manufacturer | Brand | Initiation of therapy | Length of induction phase to reach maintenance dose | Maintenance therapy |
---|---|---|---|---|
Allergopharma (manufacturer) | InfectoSlit Gräser (formerly distributed and marketed as Allerslit forte) | Preseasonal start of SLIT is recommended, then perennial therapy | Updosing on 1st day under guidance of physician | 4 drops daily, approximately 3 minutes before swallowing, thereafter 30 minutes no drinking or eating |
InfectoPharm (distributor) | ||||
ALK-Abelló | SLIToneULTRA | Perennial start possible | SLIToneULTRA is provided in single-dose containers. Induction phase duration 5–10 days. Start with 50 SRU (Standardized Reactivity Units) for 5 days. Maintenance dose is 100 SRU, 150 SRU, or 300 SRU. | 0.5 mL (one single-dose container) daily. |
Perennial intake. | ||||
ALK-Abelló | GRAZAX | Perennial start possible. | No updosing phase needed, Start with maintenance dose, first intake under guidance of physician | One grass pollen tablet daily, dissolves immediately under the tongue. |
Perennial intake. | ||||
Allergy Therapeutics | Oralvac Compact | Perennial start possible | (Classical) Updosing at home over 10 days (bottle 1 to 3) | Dosing with a pump: |
Daily 3 pumps of bottle 3, | ||||
minimum of 1–2 minutes before swallowing | ||||
or Updosing on 1st day under guidance of physician (bottle 3) | ||||
HAL Allergy | Sublivac | Perennial start possible | Updosing at home over 5 days | 5 drops daily, minimum of 1 minute, preferably 2–3 minutes before swallowing |
Laboratorios LETI | TOL forte | Preseasonal perennial | Updosing at home. Maintenance dose reached in 2 days. Single concentration. | Dosing with a pump 2 pumps daily |
Lofarma | LAIS Sublingual drops | Pre/coseasonal or perennial therapy | Updosing at home over 4 days | 6 drops daily for 120 days minimum (pre/coseasonal treatment) or 6 drops twice per week (perennial treatment), Sublingual intake minimum of 1–2 minutes before swallowing |
Lofarma | LAIS sublingual tablets | Pre/coseasonal or perennial therapy | Updosing at home over 4 days | 1 tablet daily for 120 days minimum (pre/coseasonal treatment) or 2 tablets per week (perennial treatment) tablet dissolved under the tongue over a minimum of 1 minute |
ROXALL | SULGEN Spray | Perennial start possible (also coseasonal) | Direct start with the maintenance dose at home (no updosing necessary) | 2 spray doses daily, perlingual 2 minutes before swallowing |
Stallergènes | Staloral | Preseasonal or coseasonal start, therapy interruption after season, optional perennial therapy | (Classical) Updosing at home over 11 days or Updosing on 1st day under guidance of physician (‘ultra-rush’) | 8 pumps of bottle with highest concentration daily or optionally 4 pumps daily in perennial therapy |
Stallergènes | Oralair | Preseasonal start (recommended 4 months before pollen season), coseasonal treatment, and then therapy interruption after season | Updosing at home over 3 days | One tablet (5-grass extract), dissolving over a minimum of 2 minutes |