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Table 12 Specific characteristics of some SLIT products on the market*

From: Sublingual immunotherapy: World Allergy Organization position paper 2013 update

Manufacturer

Brand

Initiation of therapy

Length of induction phase to reach maintenance dose

Maintenance therapy

Allergopharma (manufacturer)

InfectoSlit Gräser (formerly distributed and marketed as Allerslit forte)

Preseasonal start of SLIT is recommended, then perennial therapy

Updosing on 1st day under guidance of physician

4 drops daily, approximately 3 minutes before swallowing, thereafter 30 minutes no drinking or eating

InfectoPharm (distributor)

ALK-Abelló

SLIToneULTRA

Perennial start possible

SLIToneULTRA is provided in single-dose containers. Induction phase duration 5–10 days. Start with 50 SRU (Standardized Reactivity Units) for 5 days. Maintenance dose is 100 SRU, 150 SRU, or 300 SRU.

0.5 mL (one single-dose container) daily.

Perennial intake.

ALK-Abelló

GRAZAX

Perennial start possible.

No updosing phase needed, Start with maintenance dose, first intake under guidance of physician

One grass pollen tablet daily, dissolves immediately under the tongue.

Perennial intake.

Allergy Therapeutics

Oralvac Compact

Perennial start possible

(Classical) Updosing at home over 10 days (bottle 1 to 3)

Dosing with a pump:

Daily 3 pumps of bottle 3,

minimum of 1–2 minutes before swallowing

or Updosing on 1st day under guidance of physician (bottle 3)

HAL Allergy

Sublivac

Perennial start possible

Updosing at home over 5 days

5 drops daily, minimum of 1 minute, preferably 2–3 minutes before swallowing

Laboratorios LETI

TOL forte

Preseasonal perennial

Updosing at home. Maintenance dose reached in 2 days. Single concentration.

Dosing with a pump 2 pumps daily

Lofarma

LAIS Sublingual drops

Pre/coseasonal or perennial therapy

Updosing at home over 4 days

6 drops daily for 120 days minimum (pre/coseasonal treatment) or 6 drops twice per week (perennial treatment), Sublingual intake minimum of 1–2 minutes before swallowing

Lofarma

LAIS sublingual tablets

Pre/coseasonal or perennial therapy

Updosing at home over 4 days

1 tablet daily for 120 days minimum (pre/coseasonal treatment) or 2 tablets per week (perennial treatment) tablet dissolved under the tongue over a minimum of 1 minute

ROXALL

SULGEN Spray

Perennial start possible (also coseasonal)

Direct start with the maintenance dose at home (no updosing necessary)

2 spray doses daily, perlingual 2 minutes before swallowing

Stallergènes

Staloral

Preseasonal or coseasonal start, therapy interruption after season, optional perennial therapy

(Classical) Updosing at home over 11 days or Updosing on 1st day under guidance of physician (‘ultra-rush’)

8 pumps of bottle with highest concentration daily or optionally 4 pumps daily in perennial therapy

Stallergènes

Oralair

Preseasonal start (recommended 4 months before pollen season), coseasonal treatment, and then therapy interruption after season

Updosing at home over 3 days

One tablet (5-grass extract), dissolving over a minimum of 2 minutes

  1. *Modified with permission from [308, 309].