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Table 12 Specific characteristics of some SLIT products on the market*

From: Sublingual immunotherapy: World Allergy Organization position paper 2013 update

Manufacturer Brand Initiation of therapy Length of induction phase to reach maintenance dose Maintenance therapy
Allergopharma (manufacturer) InfectoSlit Gräser (formerly distributed and marketed as Allerslit forte) Preseasonal start of SLIT is recommended, then perennial therapy Updosing on 1st day under guidance of physician 4 drops daily, approximately 3 minutes before swallowing, thereafter 30 minutes no drinking or eating
InfectoPharm (distributor)
ALK-Abelló SLIToneULTRA Perennial start possible SLIToneULTRA is provided in single-dose containers. Induction phase duration 5–10 days. Start with 50 SRU (Standardized Reactivity Units) for 5 days. Maintenance dose is 100 SRU, 150 SRU, or 300 SRU. 0.5 mL (one single-dose container) daily.
Perennial intake.
ALK-Abelló GRAZAX Perennial start possible. No updosing phase needed, Start with maintenance dose, first intake under guidance of physician One grass pollen tablet daily, dissolves immediately under the tongue.
Perennial intake.
Allergy Therapeutics Oralvac Compact Perennial start possible (Classical) Updosing at home over 10 days (bottle 1 to 3) Dosing with a pump:
Daily 3 pumps of bottle 3,
minimum of 1–2 minutes before swallowing
or Updosing on 1st day under guidance of physician (bottle 3)
HAL Allergy Sublivac Perennial start possible Updosing at home over 5 days 5 drops daily, minimum of 1 minute, preferably 2–3 minutes before swallowing
Laboratorios LETI TOL forte Preseasonal perennial Updosing at home. Maintenance dose reached in 2 days. Single concentration. Dosing with a pump 2 pumps daily
Lofarma LAIS Sublingual drops Pre/coseasonal or perennial therapy Updosing at home over 4 days 6 drops daily for 120 days minimum (pre/coseasonal treatment) or 6 drops twice per week (perennial treatment), Sublingual intake minimum of 1–2 minutes before swallowing
Lofarma LAIS sublingual tablets Pre/coseasonal or perennial therapy Updosing at home over 4 days 1 tablet daily for 120 days minimum (pre/coseasonal treatment) or 2 tablets per week (perennial treatment) tablet dissolved under the tongue over a minimum of 1 minute
ROXALL SULGEN Spray Perennial start possible (also coseasonal) Direct start with the maintenance dose at home (no updosing necessary) 2 spray doses daily, perlingual 2 minutes before swallowing
Stallergènes Staloral Preseasonal or coseasonal start, therapy interruption after season, optional perennial therapy (Classical) Updosing at home over 11 days or Updosing on 1st day under guidance of physician (‘ultra-rush’) 8 pumps of bottle with highest concentration daily or optionally 4 pumps daily in perennial therapy
Stallergènes Oralair Preseasonal start (recommended 4 months before pollen season), coseasonal treatment, and then therapy interruption after season Updosing at home over 3 days One tablet (5-grass extract), dissolving over a minimum of 2 minutes
  1. *Modified with permission from [308, 309].