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Allergic diseases of the skin and drug allergies – 2006. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy


There has been growing interest in vitamin D insufficiency as a predisposing factor for allergy development based on immunoregulatory properties and epidemiological studies. The aim of this study was to investigate the association between vitamin D exposure in utero and allergic outcomes in the first year of life.


Cord blood (CB) vitamin D was measured in 231 high risk infants from an Australian prospective birth cohort. CB 25(OH)D3 concentration was analysed in relation to maternal vitamin D intake and the development of infant eczema, allergen sensitization and IgE-mediated food allergy.


Maternal intake of supplemental vitamin D was significantly correlated with CB 25(OH)D3 concentration (rho = 0.244, p = 0.003) while dietary vitamin D did not influence CB levels. There was significant seasonal variation in CB 25(OH)D3 concentration suggesting that sunlight exposure was an important determinant. Lower CB vitamin D status was observed in infants that developed eczema (p = 0.018), and eczema was significantly more likely in those with concentrations < 50 nmol/L compared with >75 nmol/L (OR 2.66; 95% CI 1.24 – 5.72; p = 0.012). This association remained significant after adjustment for multiple confounding factors. The associations between CB 25(OH)D3 concentration and allergen sensitization, IgE-mediated food allergy and eczema severity (SCORAD) were not significant.


Reduced vitamin D status in pregnancy may be a risk factor for the development of eczema in the first year of life, reinforcing the need to explore the role of vitamin D exposure during development for disease prevention.

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Correspondence to Anderson Phillip Jones.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jones, A.P., Palmer, D., Zhang, G. et al. Allergic diseases of the skin and drug allergies – 2006. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. World Allergy Organ J 6, P96 (2013).

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  • Cord Blood
  • Food Allergy
  • Allergic Disease
  • Allergen Sensitization
  • High Risk Infant