Volume 6 Supplement 1

2nd WAO International Scientific Conference (WISC 2012), Abstracts

Open Access

Environmental and occupational respiratory diseases – 1060. Clinical responses to methylprednisolone pulse therapy in children with severe refractory mycoplasma pneumoniae pneumonia

  • Jae Ho Lee1,
  • Sun Young You1,
  • Eun Ae Yang1,
  • You Sook Youn2 and
  • Hong Ryang Gil1
World Allergy Organization Journal20136:342

https://doi.org/10.1186/1939-4551-6-S1-P58

Published: 23 April 2013

Background

Mycoplasma pneumoniae (M. pneumoniae) pneumonia is one of the most common causes of community acquired pneumonia in children. The clinical course is usually self limited and benign. But rarely severe pneumonia could be complicated despite appropriate antibiotic therapy. We determine the impact of methylprednisolone pulse therapy on the severe refractory M. pneumoniae pneumonia in children.

Methods

We evaluated the clinical effects of steroid pulse therapy retrospectively in 12 children with severe refractory M. pneumoniae pneumonia, diagnosed serologically. All of the patients, who showed the respiratory distress, high fever and initial lobar pneumonic consolidation with pleural effusion radiologically, and deteriorated despite of antibiotic therapy were treated with intravenous methylprednisolone pulse therapy in addition to antibiotics.

Results

The average febrile period prior to admission was 4.9±1.7 days and that was 3.7±1.6 days after using antibiotics. We initiated methylprednisolone pulse therapy at a dose of 30mg/kg on the day 5.4±2.5 of admission. After pulse therapy, the clinical symptoms and signs were improved in all patients without adverse events of steroid therapy. In particular, the high fever was subsided within 0-2 hours after initiation of steroid pulse therapy. The abnormal radiologic findings were resolved on the days 2.6±1.3 and the high levels of C-reactive protein (6.7±5.9mg/dl on admission) was decreased to 1.3±1.7mg/dl on the days 3.0±1.1 of steroid therapy.

Conclusions

This study showed an impact of 3-day methylprednisolone pulse therapy on severe refractory M. pneumoniae pneumonia in children despite appropriate antibiotic therapy. The steroid pulse therapy is apparently an efficacious and well-tolerated treatment for severe refractory M. pneumoniae pneumonia.

Authors’ Affiliations

(1)
Pediatrics, Chungnam National University School of Medicine
(2)
Pediatrics, St Mary's Hospital, The Catholic University of Korea

Copyright

© Lee et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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