Volume 6 Supplement 1

2nd WAO International Scientific Conference (WISC 2012), Abstracts

Open Access

Asthma diagnosis and treatment – 1005. Optimization for the withdrawal of inhaled corticosteroid treatment by monitoring fractional exhaled nitric oxide (feno) and lung functions

  • Morimitsu Tomikawa1,
  • Kiyotake Ogura1,
  • Katsuhito Iikura2,
  • Noriyuki Yanagida3,
  • Sakura Sato4,
  • Takatsugu Komata2,
  • Akinori Shukuya5,
  • Yumi Koike2 and
  • Motohiro Ebisawa6
World Allergy Organization Journal20136:289


Published: 23 April 2013


There are no standardized criteria or protocol for the withdrawal of inhaled corticosteroids (ICS) from remitted pediatric asthma in Japanese Pediatric Guideline for the Treatment and Management of Asthma (JPGL).


Among 55 asthmatic subjects in our hospital, FeNO and pulmonary functions were measured at the withdrawal of ICS, at 1 month and 3 month after. Those data were investigated whether it would be a predictor for the recurrence of asthma symptoms.


Subjects in recurrent asthma symptom group were 28 cases and those of non-recurrent asthma symptom group 27 cases (relapse rate: 50.9%). Any significant factors in background patients’ profiles, such as FeNO and pulmonary functions, were not associated with the recurrence of asthma. In recurrent asthma symptom group, FeNO was significantly increased by 3 months after withdrawal of ICS (from 31.8 ppb to 49.2 ppb). Among recurrent asthma symptom group, pulmonary functions were significantly decreased within 1 months (FVC: from 2.11L to 2.02L, FEV1.0: from 1.93L to 1.85L and %FEV1.0: from 98.1% of to 93.8%).


Although these factors at the time of ICS withdrawal could not predict asthmatic revival, it is highly recommended to follow asthmatic patients who quit ICS therapy by measuring pulmonary function and FeNO periodically.

Authors’ Affiliations

Sagamihara National Hospital
National Sagamihara Hospital
Department of Pediatrics, National Sagamihara Hospital
Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital
Department of Pediatrics, National Sagamihara Hospital
Department of Allergy, Sagamihara National Hospital, Clinical Research Center


© Tomikawa et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.