Volume 6 Supplement 1

2nd WAO International Scientific Conference (WISC 2012), Abstracts

Open Access

Environmental and occupational respiratory diseases – 1045. Skin prick tests and allergen-specific IgE tests for fungus in patients with chronic lower respiratory symptoms

  • Jae Woo Jung1,
  • Jae Chol Choi1,
  • Jong Wook Shin1,
  • Jae Yeol Kim1,
  • In Won Park1 and
  • Byoung Whui Choi1
World Allergy Organization Journal20136(Suppl 1):P44

https://doi.org/10.1186/1939-4551-6-S1-P44

Published: 23 April 2013

Background

Skin prick tests (SPTs) has relatively a good correlation with allergen-specific IgE against house dust mites (HDM) and pollens, whereas their correlation to fungi remains low. We aimed to investigate the correlation between results of serum specific IgE and SPTs for HDM or fungi in patients with chronic lower respiratory symptoms. The clinical difference between serum fungus or HDM-specific IgE-positive and –negative groups was also examined.

Methods

A total of 89 patients underwent both SPT and serum specific IgE test to D. farinae, D. pteronyssiuns and 5 fungi (Penicillium notatum, Cladosporium, Aspergillus fumigatus, and Alternaria,Fusarium spp.) with chronic lower respiratory symptoms were included in this study.

Results

SPT and serum specific IgE tests for HDM were positive in 20.2% and 38.2% and for fungi 5.6% and 41.6%. The k statistic for the agreement between SPT and serum specific IgE test about HDM was relatively high (0.425, p<0.001) compared with fungi (k=0.102, P=NS). In patients with negative SPT to HDM, total IgE (741.15 vs. 84.33KU/L) was higher and FEV1 % predicted (76.95% vs. 90.33%) and PC20 (2.57 vs. 1.32mg/ml) were lower in the serum HDM-specific IgE positive group than in negative group (P<0.05). In patients with negative SPT to fungi, total IgE (480.32 vs. 119.67KU/L) was higher in the serum fungi-specific IgE positive group than in negative group (P<0.05).

Conclusions

The rate of successful detection of HDM and fungi using SPT was low compared to serum specific IgE. Thus, serum specific IgE might need to detect HDM and fungus allergies in patients with chronic lower respiratory symptoms.

Authors’ Affiliations

(1)
Internal Medicine, Chung-Ang University Hospital

Copyright

© Jung et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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