Volume 6 Supplement 1

2nd WAO International Scientific Conference (WISC 2012), Abstracts

Open Access

Asthma diagnosis and treatment – 1022. The differences of clinical profiles by house dust mite sensitzation in patients with asthmatics in Soonchunhyang University Hospital cohort

  • An-Soo Jang1,
  • Jong-Sook Park1,
  • Sung-Woo Park1,
  • June-Hyuk Lee1,
  • Dojin Kim1 and
  • Choon-Sik Park1
World Allergy Organization Journal20136(Suppl 1):P21

https://doi.org/10.1186/1939-4551-6-S1-P21

Published: 23 April 2013

Background

The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort.

Methods

We recruited 2316 asthmatic patients in SCH cohort. Lung function, BMI and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization.

Results

HDM sensitization rate was higher prevalence in male than in female. Compared with non-HDM sensitization asthmatics, HDM positive asthmatics had early onset of age (D. farina, 39.0 ± 0.50 vs. 48.5 ± 0.42, p=0.001; D. pteronyssinus, 39.4 ± 0.50 vs. 48.3 ± 0.43, p=0.001). HDM positive asthmatics had shorter duration of asthma symptom than that of HDM negative asthmatics. HDM negative asthmatics had lower FEV1/FVC % than those of HDM positive asthmatics. PC20 in HDM positive asthmatics had lower than those of HDM negative asthmatics (D. farina, 5.59 ± 0.25 mg/ml vs. 6.82 ± 0.28 mg/ml, p=0.001; D. pteronyssinus, 5.54 ± 0.24 mg/ml vs. 6.87 ± 0.28 mg/ml, p=0.001). Blood eosinophils number in D. pteronyssinus positive asthmatics had higher than that of D. pteronyssinus negative asthmatics (400.7 ± 12.5 vs. 373.5 ± 15.3, p<0.05). Total IgE in HDM positive asthmatics had higher than that of HDM negative asthmatics. There was no difference of BMI between two groups.

Conclusions

Our data indicate that atopy asthmatics who sensitized to HDM had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation.

Authors’ Affiliations

(1)
Soonchunhyang University Bucheon Hospital

Copyright

© Jang et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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