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  • Meeting abstract
  • Open Access

Rhinitis, sinusitis and ocular disease – 2098. Exhaled NO may predict development of allergic rhinitis in children with asthma

  • 1 and
  • 1
World Allergy Organization Journal20136:457

  • Published:


  • Nitric Oxide
  • Asthma
  • Dermatitis
  • Atopic Dermatitis
  • Rhinitis


As a non-invasive parameter of lower airway inflammation, fraction of exaled nitric oxide (FeNO) concentration has been known to be related with bronchial hyperreactivity in asthma patient. FeNO may be increased in atopy related diseases (e.g. allergic rhinitis) but relationship of FeNO and development of allergic rhinitis in asthma is unknown. The aim of this study was to investigate whether measurement of FeNO in asthma children can predict development of allergic rhinitis.


Fifty-three children with mild to moderate persistent asthma aged from 5 to 15 years who were measured with FeNO, total eosinophil count and IgE were included. FeNO was measured through chemiluminescence analyzer. Prospectively, the patients were followed after 6 years by interview with questionnaire and FeNO levels of the patient who developed allergic rhinitis (allergic rhinitis group and who do not manifest allergic rhinitis (control group) were evaluated.


There were no difference of peripheral blood total eosinophil count, serum IgE, age, sex, family history, history of atopic dermatitis, or degree of asthma severity between allergic rhinitis group and control group. FeNO was significantly higher in allergic rhinitis group compared to control group (29.4 vs 24.6 parts per billion [ppb] vs 13.6 vs 11.8 ppb; p = 0.003).


Measurement of FeNO can be a useful tool to predict to predict development of allergic rhinitis in asthmatic children.

Authors’ Affiliations

Department of Pediatrics, Kyung Hee University Hospital, Seoul, South Korea


© Rha and Ko; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.