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Rhinitis, sinusitis and ocular disease – 2088. Evaluation of blood markers for determination of atopy in Indian patients with symptoms of respiratory allergy


The cause of allergy-like symptoms may be due to IgE mediated allergy, but also because of other mechanisms.There is a need to find a simple and convenient test to identify/exclude atopy for a correct and proper patient management in patients with respiratory allergies in India.


105 patients (18-60 years) with a clinical diagnosis of asthma and/or rhinitis, based only on clinical history and physical examination,visiting an Otolaryngology department in a tertiary hospital were included in the study. Phadiatop, a test with extensive data published in the West showing >90% sensitivity and specificity, was used as the gold standard for atopy. Phadiatop measures IgE antibodies to a balanced mixture of common environmental allergens relevant for the geographical area and the age of the patients (adults). For each patient the result of Phadiatop was compared with: I. Clinical history (Hx), II. Total IgE level (T-IgE) and III. Absolute Eosinophil Count (AEC).


Phadiatop revealed atopy in 69% (72/105) of the patients, which means that approx. 1/3 of the patients diagnosed with IgE-mediated allergy by Hx in fact were not allergic.The sensitivity for atopic disease was 90.3% and 33.3% for T-IgE and AEC, respectively. Among the 33 patients with positive Hx but negative Phadiatop; 7 patients had increased T-IgE level and 8 had increased AEC, however only one patient with both tests positive. The efficiency of T-IgE and AEC to diagnose atopic allergy was 83.8% and 46.7% respectively, compared with Phadiatop.


Diagnosing patients with allergy-like respiratory symptoms is difficult without using any tests; by Hx only, the allergy diagnosis was overestimated in more than 30% of the cases, which is in agreement with earlier findings. Although valuable, a good clinical history is not definitive. The results from this study suggest that Phadiatop could be a very useful and cost saving initial test in India when differentiating between atopic and non-atopic allergy, but further investigations of the Indian allergen coverage may be needed.

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Correspondence to Vattikonda Sathavahana Chowdary.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chowdary, V.S. Rhinitis, sinusitis and ocular disease – 2088. Evaluation of blood markers for determination of atopy in Indian patients with symptoms of respiratory allergy. World Allergy Organ J 6, P167 (2013).

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  • Rhinitis
  • Sinusitis
  • Atopic Disease
  • Respiratory Allergy
  • Environmental Allergen