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  • Meeting abstract
  • Open Access

Food allergy and anaphylaxis – 2056. Clinical cross-reactivity of major food allergens among children

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World Allergy Organization Journal20136:423

  • Published:


  • Food Allergy
  • Food Allergen
  • Elimination Diet
  • Oral Food Challenge
  • Allergy Patient


There are some reports on cross-reactivity among food allergens based on serological tests. On the other hand, actual frequency of cross-reactivity among food allergens based on clinical symptoms or results of oral food challenge (OFC) has not been reported.


We sought to clarify information of elimination diets related to clinical cross-reactivity of childhood major food allergens (hen’s egg, cow’s milk, wheat, soybean, and peanuts). We reviewed clinical records of patients who had visited to our department from January to December in 2010. One thousand eight hundreds twenty-two patients (1207 males and 615 females) were recruited to this study.


Patients’ profiles were as follows; average age 5y8m+/-3y8m (mean+/-SD); number of eliminated foods 2.1+/-1.4 items per patient. Patients had been diagnosed mostly based on definitive clinical symptoms or results of OFC, but some patients had avoided foods based on elevated antigen-specific IgE tests. In 1226 patients with hen’s egg allergy, only 2 patients (0.2%) had avoided chicken, 44 (3.6%) salmon roe, and 16 (0.1%) other kind of fish eggs. In 771 cow’s milk allergy patients, 3 patients (0.4%) had avoided beef. In 392 wheat allergy patients, 5 patients (1.2%) had removed other grains such as barley and rye. In 72 soybean allergy patients, 23 patients (31.9%) had removed peanuts, on the other hand, in 445 patients avoiding peanuts, 24 (5.4%) had avoided soybean. Moreover 81 of 445 (18.2%) patients avoiding peanuts had eliminated tree nuts. Seventy-two patients with soy bean allergy had not avoided any other legumes.


Based on definitive clinical symptoms or results of OFC, we could reveal that frequency of elimination diets associated with cross-reactivity of the major food allergens was much lower than that reported by serological tests.

Authors’ Affiliations

Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Japan
Natinal Sagamihara Hospital, Japan
Sagamihara National Hospital, Japan
Department of Pediatrics, Natinal Sagamihara Hospital, Sagamihara, Japan
Department of Allergy, Sagamihara National Hospital, Clinical Research Center, Japan


© Hasegawa et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.