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Food allergy and anaphylaxis – 2055: Slow specific oral tolerance induction in children with hen’s egg allergy. 3-days on / 4 days off schedule

Background

Specific oral tolerance induction (SOTI) therapy has been used for treat children with food allergy. Patients usually intake food allergens every day in slow-SOTI protocol, but other protocols have not yet been evaluated.

Objective

The aim of this study is to evaluate the efficacy of SOTI with 3-days on/4-days off schedule per one week for children with hen’s egg allergy.

Methods

Seven children aged 9 months to 6.6 years (median 1.7 years) with hen’s egg allergy were performed open oral food challenge tests with boiled hen’s egg to define the threshold dose. Subjects underwent SOTI in which they intake boiled hen’s egg at home 3 days every week. The dose was increased every 1 to 2 weeks from approximately one fourth of the threshold dose to 60g. Clinical response and immunologic changes before and after SOTI were evaluated.

Results

Six of 7 subjects (85.7%) could intake higher doses of boiled egg more than the threshold doses. It took 30 to 121 days (median 51 days). Serum total immunoglobulin E (IgE) changed from 297 IU/ml (mean of six patients) to 294 IU/ml, egg white-specific immunoglobulin E (sIgE) increased from 10.1 UA/ml to 16.1 UA/ml, ovomucoid sIgE increased from 4.2 UA/ml to 6.7 UA/ml, peripheral eosinophils counts decreased from 550/μl to 472μ/l , and wheal size in skin prick test decreased from 4.4mm (mean diamiter) to 2.7mm after SOTI.

Conclusions

Three-days on/4-days off schedule in slow SOTI is comparable to everyday schedule for patients with hen’s egg allergy.

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Correspondence to Kentaro Mikami.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mikami, K., Ogawa, N., Ogawa, N. et al. Food allergy and anaphylaxis – 2055: Slow specific oral tolerance induction in children with hen’s egg allergy. 3-days on / 4 days off schedule. World Allergy Organ J 6, P138 (2013). https://doi.org/10.1186/1939-4551-6-S1-P138

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  • DOI: https://doi.org/10.1186/1939-4551-6-S1-P138

Keywords

  • Food Allergy
  • Skin Prick Test
  • Food Allergen
  • Threshold Dose
  • Food Challenge