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Asthma diagnosis and treatment – 1013. Six month follow up on pediatric patients with severe persistent allergic asthma after on eyear of omalizumb therapy

Purpose

Anti-IgE antibody had been used in severe persistent allergic asthma in adults. However, its long-term efficacy in pediatric patients in India has not been reported.

Method

20 pediatric (12 male and 8 female) patients, with mean age of 8.5 having severe persistent allergic asthma, with recurrent exacerbations and on oral/IV steroids, prospectively received Omalizumab 150mg/300mg, depending on IgE & body weight for 6 month to 1 year,at B.R.Singh Hospital, Kolkata. Number of exacerbations, total dose of oral Steroids, use of rescue medications, ICS/LABA dose used were recorded at the baseline, 24 weeks, end of treatment and on 6 month follow up (between February 2011 and August 2012) and statistically analyzed.

Results

All 20 patients after anti-IgE therapy were followed-up for 6months.Significant reductions observed in total oral steroid use by six months -15.5mg (27.5mg vs. 12mg; 95%CI, p<0.001). Use of rescue medications with β2 agonists inhalerdecreased by -7.90 puffs (12.0 vs 4.10 puffs; 95%CI, p-value <0.001) at 24 weeks and by -13.67 puffs (13.67 vs 0.00 puffs; 95%CI, p-value <0.001) at 52 weeks (n=6). There was significant reduction in ICS dose at week 24 by -287.50 mcg (550.0 vs 262.50 mcg; 95%CI, p-value <0.001). By week 52 (n=6) ICS dose further declined to -458.33 mcg (750.0 vs 291.67 mcg; 95%CI, p-value <0.001). 15 (75%) patients had severe asthma symptoms at baseline,which came down to 6 (30%) (p<0.05), at week 24. Similarly 15 (75%) patients had unscheduled hospitalization at baseline, this figure came down to zero by week 24.

Conclusion

Use of anti-IgE antibody for 6 months to 1 year is well tolerated and led to overall significant improvement and stabilization of pediatric patients with severe persistent allergic asthma which was maintained at 6 months post treatment follow-up period.

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Correspondence to Tarun Choudhuri.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Choudhuri, T. Asthma diagnosis and treatment – 1013. Six month follow up on pediatric patients with severe persistent allergic asthma after on eyear of omalizumb therapy. World Allergy Organ J 6, P13 (2013). https://doi.org/10.1186/1939-4551-6-S1-P13

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  • DOI: https://doi.org/10.1186/1939-4551-6-S1-P13

Keywords

  • Asthma
  • Pediatric Patient
  • Severe Asthma
  • Asthma Symptom
  • Rescue Medication