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Allergic diseases of the skin and drug allergies – 2032. Epidemiological study of a specific unit of drug allergy diagnosis - 20 years experience

Background

To determine the allergy incidence to drugs in patients visited in our unit with a clinical history suggestive of allergic hypersensitivity to one or more drugs. Our area of influence is the whole region of Catalonia, North-East of Spain.

Methods

We use our own method of diagnosis; keeping in mind the limitations in our medical practice such as a difficult anamnesis; few standardised skin tests for most substances; and the scarce reliability of the in-Vitro tests. The provocation test was the gold standard of the definitive diagnosis.

Results

33750 patients have been studied in 20 years; each patient has undergone an average of 1.4 tests 68% of them being female and 32% male.

Conclusions

A positive result was found in 20% of the studied cases; 8% of these related to placebo. The most studied drugs have been the beta lactamates (50%), non-steroid anti-inflamatories (NSAIDs) (30%), local anesthesics (10%), others (10%).

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marti, E., Scorza, E. Allergic diseases of the skin and drug allergies – 2032. Epidemiological study of a specific unit of drug allergy diagnosis - 20 years experience. World Allergy Organ J 6, P118 (2013). https://doi.org/10.1186/1939-4551-6-S1-P118

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  • DOI: https://doi.org/10.1186/1939-4551-6-S1-P118

Keywords

  • Gold
  • Placebo
  • Positive Result
  • Epidemiological Study
  • Gold Standard