Table 2 The levels and frequency of detection of IgE- and IgG-abs to tissue antigens in children of preschool age with AD
Severity of AD | Amount of patients | Levels of total IgE KU/l | Antigens | Cut-off | Level of abs (QR) to tissue antigens | Frequency of occurrence of abs, % | |||
|---|---|---|---|---|---|---|---|---|---|
IgE-abs МЕ/ml | IgG-abs μg/ml | IgE-abs МЕ/ml | IgG-abs μg/ml | IgE-abs | IgG-abs | ||||
Mild | 23 | 26.5 (68) | Keratin | 1.48 | 255 | 1.4 (5.6)* | 149.2 (128)* | 30.4* | 21.7* |
Collagen VI | 1.4 | 73 | 1.4 (0.6) | 67.3 (111) | 34.8 | 43.5 | |||
Elastin | 1.4 | 48 | 1.4 (1.0)* | 25 (16.3) | 34.8* | 21.7 | |||
Collagen III | 1.4 | 147 | 1.4 (−) | 62.8 (41.9) | 21.7 | 8.7 | |||
Myosin | 3.1 | 154 | 2.06 (2.4) | 53.7 (76.8) | 34.8 | 8.7 | |||
Moderate | 41 | 107 (275) | Keratin | 1.48 | 255 | 1.67 (7.8) | 260.8 (97.4) | 60.0 | 56.1 |
Collagen VI | 1.4 | 73 | 1.4 (1.2) | 64.8 (56.5) | 48.8 | 41.5 | |||
Elastin | 1.4 | 48 | 1.78 (2.5) | 25 (27.1) | 53.7 | 26.8 | |||
Collagen III | 1.4 | 147 | 1.4 (3.17) | 73.7 (88.4) | 48.8 | 19.5 | |||
Myosin | 3.1 | 154 | 2.88 (9.0) | 83 (162.3) | 46.3 | 26.8 | |||
Severe | 39 | 360 (1080) | Keratin | 1.48 | 255 | 2.16 (5.58)* ** | 291.5 (496.6)* ** | 61.5* | 56.4* |
Collagen VI | 1.4 | 73 | 1.4 (−) | 27.2 (26.7) | 15.4 | 15.4 | |||
Elastin | 1.4 | 48 | 1.81 (0.49)* ** | 25 (16.9) | 53.9* | 23.1 | |||
Collagen III | 1.4 | 147 | 1.4 (−) | 25 (40.3) | 12.8 | 5.1 | |||
Myosin | 3.1 | 154 | 1.4 (−) | 40.8 (104.5) | 10.3 | 20.5 | |||