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Table 1 Evidence of the immunomodulatory capacity of the living environment in humans

From: The biodiversity hypothesis and allergic disease: world allergy organization position statement

Evidence from Altered susceptibility to References
Immigrant studies Allergic diseases [74, 75, 77, 78]
  Type 1 diabetes [73]
  Multiple sclerosis [76]
  Obesity, type 2 diabetes [79]
  Depression [80]
  Cancers [81]
Epigenetic studies   
Microbial deprivation Allergic diseases [111, 117, 118]
Air pollution Asthma deterioration [119]
Studies on the gut and skin microbiota   
Microbial deprivation, altered composition Allergic diseases [8, 5154]
  1. Data on altered susceptibility to inflammatory diseases are for immigrants moving from less affluent to affluent countries, except in ref [76].