Tolerance can be endorsed by behavioral means including physical training, consumption of healthy diet and doing activities in natural environments. These things should be included also in secondary prevention together with specific immunotherapy. Unspecific and specific means to endorse tolerance act in synergy. Natural Killer (NK) cells and Natural Killer T (NKT) cells share characteristics of both innate and acquired immunity. SIT=Specific Immunotherapy, SLIT=Specific Oral Immunotherapy.