|
Aminoglycosides
|
CD, U, MPE, FDE, TEN, DIHS, ANA
|
PT
|
1-20%
|
|
STs
|
0.1 ng/mL-20 mg/mL
|
|
Chloramphenicol
|
ANA, fever, U, AE, MPE, AGEP, CD, bullous eruption, EM, FDE, SJS, TEN, bronchospasm, aplastic anemia
|
STs
|
-
|
|
PT
|
1%
|
|
Clindamycin
|
MPE, ANA, U, AE, FDE, bullous eruptions, AGEP, Sweet’s syndrome, SJS, DIHS
|
OPT
|
-
|
|
PT
|
10%
|
|
Dapsone
|
Methemoglobinemia, agranulocytosis
|
Methemoglobin measurement
|
-
|
|
Ethambutol
|
Skin rash, ED, U, AE, EM, SJS, TEN, blood eosinophilia, pulmonary infiltrates, hepatitis, vomiting, thrombocytopenia, flu-like syndrome, arthralgia, neuropsychiatric symptoms, optic neuritis
|
PT
|
10-50%
|
|
Isoniazid
|
MPE, lichenoid rash, flushing, DIHS, SJS, pruritus, drug fever, peripheral neuropathy, hepatitis
|
Graded challenge
|
-
|
|
Macrolides
|
U, AE, RC, ANA, MPE, CD, FDE, TEN
|
STs
|
Erythromycin 0.05 mg/mL
|
|
Azithromycin 0.01 mg/mL
|
|
Roxythromycin 50 mg/mL
|
|
Clarithromycin 0.5 mg/mL
|
|
PT
|
10%
|
|
OPT
|
-
|
|
Pyrazinamide
|
Flushing, itchy rash, ANA, hepatitis
|
STs
|
500 mg/mL
|
|
Quinolones
|
U, ANA, MPE, FDE, photoallergy, AGEP, SJS, TEN
|
STs
|
Levofloxacin 5 mg/mL
|
|
Ciprofloxacin 2 mg/mL
|
|
Moxifloxacin 1.6 mg/mL
|
|
OPT
| |
|
Rifampicin
|
Flushing, flu-like syndrome, MPE, pemphigus, lupus erythematosus, SJS, TEN, ANA, thrombocytopenia, nephrotoxicity, hepatitis, hemolytic anemia
|
STs
|
1: 10000
|
|
Streptomycin
|
Skin rash, ANA, ototoxicity, nephrotoxicity, MPE, U, ED, SJS, DIHS
|
PT
|
20%
|
|
Sulphamethoxazole
|
Nausea, haemopoietic disorders, porphyria, ANA, haemolyitc anemia, MPE, SJS, TEN, DIHS
|
STs
|
80 mg/mL
|
|
PT
|
10%
|
|
LTT
| |
|
Telithromycin
|
Hepatotoxicity, U, AE, ANA, TEN
|
OPT
|
-
|
|
Tetracyclines
|
FDE, DIHS, TEN, hepatitis, pneumonitis, ANA, phototoxic and photallergic reactions
|
STs
|
Doxycicline :prick 20 mg/mL; id: 2 mg/mL
|
|
PT
|
5%
|
|
Vancomycin
|
RMS, ANA, SJS, ED, TEN, FDE, vasculitis, DIHS, AGEP, linear IgA bullous dermatosis, nephropathy
|
STs
|
0.1 mg/mL
|
| | |
PT
|
0.005%
|
