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Table 4 Observations Supporting Interrelationships Between Cysteinyl-Leukotrienes and the Atopic Condition

From: Pancake Syndrome (Oral Mite Anaphylaxis)

• Excessive production of leukotrienes in patients with hypersensitivity to NSAIDs
• Increased prevalence of atopy (allergy to mites) in patients with hypersensitivity to NSAIDs
• A genetic polymorphism of LTC 4 synthase gene is present in patients with NSAID hypersensitivity
• A genetic polymorphism of LTC 4 synthase gene regulates the production of specific IgE
• "Atopic" and LTC 4 S loci are located closely in chromosome 5
• Genetic polymorphisms of leukotriene receptor genes are associated with atopy
• Leukotrienes enhance the production of IgE by human B cells
• IL-4 and IL-13 increase the number of leukotriene receptors
• Acetylsalycilic acid enhances food-induced anaphylaxis and food-dependent exercise-induced anaphylaxis
• Patients with oral mite anaphylaxis show increased prevalence of NSAID hypersensitivity
• Mite allergenic extracts inhibit cyclooxygenase activity in vitro