Table 4 Observations Supporting Interrelationships Between Cysteinyl-Leukotrienes and the Atopic Condition

• Excessive production of leukotrienes in patients with hypersensitivity to NSAIDs

• Increased prevalence of atopy (allergy to mites) in patients with hypersensitivity to NSAIDs

• A genetic polymorphism of LTC ₄ synthase gene is present in patients with NSAID hypersensitivity

• A genetic polymorphism of LTC ₄ synthase gene regulates the production of specific IgE

• "Atopic" and LTC ₄ S loci are located closely in chromosome 5

• Genetic polymorphisms of leukotriene receptor genes are associated with atopy

• Leukotrienes enhance the production of IgE by human B cells

• IL-4 and IL-13 increase the number of leukotriene receptors

• Acetylsalycilic acid enhances food-induced anaphylaxis and food-dependent exercise-induced anaphylaxis

• Patients with oral mite anaphylaxis show increased prevalence of NSAID hypersensitivity

• Mite allergenic extracts inhibit cyclooxygenase activity in vitro