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Table 2 Hematopoietic Neoplasms Accompanied by Eosinophilia

From: ICON: Eosinophil Disorders

Neoplasms in which eosinophils are likely to be clonal cells
   Acute eosinophilic leukemia
   Acute myeloid leukemia with inv(16) (FAB AML M4eo)
   Chronic myeloid leukemia
   Myeloid neoplasms with PDGFR abnormalities (WHO types)
   Hematopoietic neoplasms with FGFR1 abnormalities (WHO types)
   Smoldering systemic mastocytosis
   Aggressive systemic mastocytosis
   Mast cell leukemia
Neoplasms in which eosinophils may or may not be part of the malignant clone
   Other MPN with eosinophilia*
   MDS with eosinophilia
   Other MDS/MPN overlap syndromes with eosinophilia*
   Indolent systemic mastocytosis
Neoplasms in which eosinophils usually are not part of the malignant clone
   Hodgkin disease
   B-or T-cell non-Hodgkin lymphoma
   Acute lymphoblastic leukemia
   Chronic lymphocytic leukemia
   Langerhans cell histiocytosis
  1. *Other MPN or MPN/MDS: neoplasms where no abnormalities in the PDGFR or FGFR1 genes are detectable.
  2. CEL, chronic eosinophilic leukemia; PDGFR, platelet-derived growth factor receptor; FGFR, fibroblast growth factor receptor; MPN, myeloproliferative neoplasm (s); MDS, myelodysplastic syndrome(s).
  3. WHO, World Health Organization.